| http://purl.uniprot.org/citations/20308281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20308281 | http://www.w3.org/2000/01/rdf-schema#comment | "The components of receptor tyrosine kinase signaling complexes help to define the specificity of the effects of their activation. The Caenorhabditis elegans fibroblast growth factor receptor (FGFR), EGL-15, regulates a number of processes, including sex myoblast (SM) migration guidance and fluid homeostasis, both of which require a Grb2/Sos/Ras cassette of signaling components. Here we show that SEM-5/Grb2 can bind directly to EGL-15 to mediate SM chemoattraction. A yeast two-hybrid screen identified SEM-5 as able to interact with the carboxy-terminal domain (CTD) of EGL-15, a domain that is specifically required for SM chemoattraction. This interaction requires the SEM-5 SH2-binding motifs present in the CTD (Y(1009) and Y(1087)), and these sites are required for the CTD role of EGL-15 in SM chemoattraction. SEM-5, but not the SEM-5 binding sites located in the CTD, is required for the fluid homeostasis function of EGL-15, indicating that SEM-5 can link to EGL-15 through an alternative mechanism. The multi-substrate adaptor protein FRS2 serves to link vertebrate FGFRs to Grb2. In C. elegans, an FRS2-like gene, rog-1, functions upstream of a Ras/MAPK pathway for oocyte maturation but is not required for EGL-15 function. Thus, unlike the vertebrate FGFRs, which require the multi-substrate adaptor FRS2 to recruit Grb2, EGL-15 can recruit SEM-5/Grb2 directly."xsd:string |
| http://purl.uniprot.org/citations/20308281 | http://purl.org/dc/terms/identifier | "doi:10.1534/genetics.109.113373"xsd:string |
| http://purl.uniprot.org/citations/20308281 | http://purl.uniprot.org/core/author | "Bennett D.C."xsd:string |
| http://purl.uniprot.org/citations/20308281 | http://purl.uniprot.org/core/author | "Goodman S.J."xsd:string |
| http://purl.uniprot.org/citations/20308281 | http://purl.uniprot.org/core/author | "Stern M.J."xsd:string |
| http://purl.uniprot.org/citations/20308281 | http://purl.uniprot.org/core/author | "Lo T.W."xsd:string |
| http://purl.uniprot.org/citations/20308281 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20308281 | http://purl.uniprot.org/core/name | "Genetics"xsd:string |
| http://purl.uniprot.org/citations/20308281 | http://purl.uniprot.org/core/pages | "537-547"xsd:string |
| http://purl.uniprot.org/citations/20308281 | http://purl.uniprot.org/core/title | "Caenorhabditis elegans fibroblast growth factor receptor signaling can occur independently of the multi-substrate adaptor FRS2."xsd:string |
| http://purl.uniprot.org/citations/20308281 | http://purl.uniprot.org/core/volume | "185"xsd:string |
| http://purl.uniprot.org/citations/20308281 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20308281 |
| http://purl.uniprot.org/citations/20308281 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20308281 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AVM0-mappedCitation-20308281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20308281 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AYK2-mappedCitation-20308281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20308281 |
| http://purl.uniprot.org/uniprot/#_A0A0K3AYL0-mappedCitation-20308281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20308281 |
| http://purl.uniprot.org/uniprot/#_A0A0K3ASS4-mappedCitation-20308281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20308281 |
| http://purl.uniprot.org/uniprot/#_A0A0K3ATB0-mappedCitation-20308281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20308281 |
| http://purl.uniprot.org/uniprot/#_A0A0K3ATB5-mappedCitation-20308281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20308281 |
| http://purl.uniprot.org/uniprot/#_A0A5E4LZH0-mappedCitation-20308281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20308281 |
| http://purl.uniprot.org/uniprot/#_A0A5E4LZL8-mappedCitation-20308281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20308281 |
| http://purl.uniprot.org/uniprot/#_A0A4V0ILE7-mappedCitation-20308281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20308281 |
| http://purl.uniprot.org/uniprot/#_E6N0V1-mappedCitation-20308281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20308281 |
| http://purl.uniprot.org/uniprot/#_G5EDP9-mappedCitation-20308281 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20308281 |