| http://purl.uniprot.org/citations/20308558 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20308558 | http://www.w3.org/2000/01/rdf-schema#comment | "Primary cilia are microtubule-based membrane projections located at the surface of many cells. Defects in primary cilia formation have been implicated in a number of genetic disorders, such as Bardet-Biedl Syndrome and Polycystic Kidney Disease. Recent studies have demonstrated that polarized vesicular transport involving Rab8 and its guanine nucleotide-exchange factor Rabin8 is essential for primary ciliogenesis. Here we report that Rabin8 is a direct downstream effector of Rab11, which functions in membrane trafficking from the trans-Golgi network and recycling endosomes. Rab11, in its GTP-bound form, interacts with Rabin8 and kinetically stimulates the guanine nucleotide-exchange activity of Rabin8 toward Rab8. Rab11 is enriched at the base of the primary cilia and inhibition of Rab11 function by a dominant-negative mutant or RNA interference blocks primary ciliogenesis. Our results suggest that Rab GTPases coordinate with each other in the regulation of vesicular trafficking during primary ciliogenesis."xsd:string |
| http://purl.uniprot.org/citations/20308558 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.1002401107"xsd:string |
| http://purl.uniprot.org/citations/20308558 | http://purl.uniprot.org/core/author | "Feng S."xsd:string |
| http://purl.uniprot.org/citations/20308558 | http://purl.uniprot.org/core/author | "Das A."xsd:string |
| http://purl.uniprot.org/citations/20308558 | http://purl.uniprot.org/core/author | "Guo W."xsd:string |
| http://purl.uniprot.org/citations/20308558 | http://purl.uniprot.org/core/author | "Zhang X."xsd:string |
| http://purl.uniprot.org/citations/20308558 | http://purl.uniprot.org/core/author | "Zhang J."xsd:string |
| http://purl.uniprot.org/citations/20308558 | http://purl.uniprot.org/core/author | "Peranen J."xsd:string |
| http://purl.uniprot.org/citations/20308558 | http://purl.uniprot.org/core/author | "Knodler A."xsd:string |
| http://purl.uniprot.org/citations/20308558 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20308558 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/20308558 | http://purl.uniprot.org/core/pages | "6346-6351"xsd:string |
| http://purl.uniprot.org/citations/20308558 | http://purl.uniprot.org/core/title | "Coordination of Rab8 and Rab11 in primary ciliogenesis."xsd:string |
| http://purl.uniprot.org/citations/20308558 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/20308558 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20308558 |
| http://purl.uniprot.org/citations/20308558 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20308558 |
| http://purl.uniprot.org/uniprot/#_B4DMN1-mappedCitation-20308558 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20308558 |
| http://purl.uniprot.org/uniprot/#_B4DQU5-mappedCitation-20308558 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20308558 |
| http://purl.uniprot.org/uniprot/#_Q13563-mappedCitation-20308558 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20308558 |
| http://purl.uniprot.org/uniprot/#_Q14028-mappedCitation-20308558 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20308558 |
| http://purl.uniprot.org/uniprot/#_P08100-mappedCitation-20308558 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20308558 |
| http://purl.uniprot.org/uniprot/#_P24386-mappedCitation-20308558 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20308558 |
| http://purl.uniprot.org/uniprot/#_P50395-mappedCitation-20308558 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20308558 |
| http://purl.uniprot.org/uniprot/#_Q16280-mappedCitation-20308558 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20308558 |