| http://purl.uniprot.org/citations/20308568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20308568 | http://www.w3.org/2000/01/rdf-schema#comment | "A proportion of classical Hodgkin lymphoma (HL) is believed to be causally related to infection with the ubiquitous lymphotropic EBV. The determining factors for development of EBV-related HL remain poorly understood, but likely involve immunological control of the viral infection. Accordingly, markers of the HLA class I region have been associated with risk of EBV-related HL. To study the host genetic component of EBV-related HL further, we investigated the lymphoma's association with HLA-A*01 and HLA-A*02 simultaneously in the setting of infectious mononucleosis (IM), a risk factor for EBV-related HL, in a case-series analysis including 278 EBV-related and 656 EBV-unrelated cases of HL. By logistic regression, HLA-A*01 alleles [odds ratio (OR) per allele, 2.15; 95% CI, 1.60-2.88] were associated with increased and HLA-A*02 alleles (OR per allele, 0.70; 95% CI, 0.51-0.97) with decreased risk of EBV-related HL. These allele-specific associations corresponded to nearly 10-fold variation in risk of EBV-related HL between HLA-A*01 and HLA-A*02 homozygotes. History of IM was also associated with risk of EBV-related HL (OR, 3.40; 95% CI, 1.74-6.66). The association between history of IM and EBV-related HL was not seen in the presence of HLA-A*02 because this allele appeared to neutralize the effect of IM on EBV-related HL risk. Our findings suggest that HLA class I-restricted EBV-specific cytotoxic T-cell responses and events in the early immune response to EBV infection in IM play critical roles in the pathogenesis of EBV-related HL."xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0915054107"xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/author | "Taylor G.M."xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/author | "Andersen P.S."xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/author | "Lake A."xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/author | "Little A.M."xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/author | "Hjalgrim H."xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/author | "Sundstrom C."xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/author | "Chang E.T."xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/author | "Ryder L.P."xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/author | "Kane E."xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/author | "Jarrett R.F."xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/author | "Johnson P.C."xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/author | "Melbye M."xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/author | "Rostgaard K."xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/author | "Alexander F.E."xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/author | "Adami H.O."xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/author | "Shield L."xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/author | "Glimelius B."xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/author | "Hamilton-Dutoit S."xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/author | "Ekstrom-Smedby K."xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/author | "McConnachie A."xsd:string |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20308568 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |