| http://purl.uniprot.org/citations/20308599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20308599 | http://www.w3.org/2000/01/rdf-schema#comment | "The murine gut epithelium contains a large population of thymus-derived intraepithelial lymphocytes (IELs), including both conventional CD4(+) and CD8alphabeta(+) T cells (expressing T-cell receptor alphabeta [TCRalphabeta]) and unconventional CD8alphaalpha(+) T cells (expressing either TCRalphabeta or TCRgammadelta). Whereas conventional IELs are widely accepted to arise from recirculation of activated CD4(+) and CD8alphabeta(+) T cells from the secondary lymphoid organs to the gut, the origin and developmental pathway of unconventional CD8alphaalpha IELs remain controversial. We show here that CD4-Cre-mediated inactivation of c-Myc, a broadly expressed transcription factor with a wide range of biologic activities, selectively impairs the development of CD8alphaalpha TCRalphabeta IELs. In the absence of c-Myc, CD4(-) CD8(-) TCRalphabeta(+) thymic precursors of CD8alphaalpha TCRalphabeta IELs are present but fail to develop on adoptive transfer in immunoincompetent hosts. Residual c-Myc-deficient CD8alphaalpha TCRalphabeta IEL display reduced proliferation and increased apoptosis, which correlate with significantly decreased expression of interleukin-15 receptor subunits and lower levels of the antiapoptotic protein Bcl-2. Transgenic overexpression of human BCL-2 resulted in a pronounced rescue of CD8alphaalpha TCRalphabeta IEL in c-Myc-deficient mice. Taken together, our data support a model in which c-Myc controls the development of CD8alphaalpha TCRalphabeta IELs from thymic precursors by regulating interleukin-15 receptor expression and consequently Bcl-2-dependent survival."xsd:string |
| http://purl.uniprot.org/citations/20308599 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2009-11-254698"xsd:string |
| http://purl.uniprot.org/citations/20308599 | http://purl.uniprot.org/core/author | "Jiang W."xsd:string |
| http://purl.uniprot.org/citations/20308599 | http://purl.uniprot.org/core/author | "Ferrero I."xsd:string |
| http://purl.uniprot.org/citations/20308599 | http://purl.uniprot.org/core/author | "Trumpp A."xsd:string |
| http://purl.uniprot.org/citations/20308599 | http://purl.uniprot.org/core/author | "MacDonald H.R."xsd:string |
| http://purl.uniprot.org/citations/20308599 | http://purl.uniprot.org/core/author | "Laurenti E."xsd:string |
| http://purl.uniprot.org/citations/20308599 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20308599 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/20308599 | http://purl.uniprot.org/core/pages | "4431-4438"xsd:string |
| http://purl.uniprot.org/citations/20308599 | http://purl.uniprot.org/core/title | "c-Myc controls the development of CD8alphaalpha TCRalphabeta intestinal intraepithelial lymphocytes from thymic precursors by regulating IL-15-dependent survival."xsd:string |
| http://purl.uniprot.org/citations/20308599 | http://purl.uniprot.org/core/volume | "115"xsd:string |
| http://purl.uniprot.org/citations/20308599 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20308599 |
| http://purl.uniprot.org/citations/20308599 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20308599 |
| http://purl.uniprot.org/uniprot/#_E0CZD1-mappedCitation-20308599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20308599 |
| http://purl.uniprot.org/uniprot/#_A0A1B0GQZ2-mappedCitation-20308599 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20308599 |
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