| http://purl.uniprot.org/citations/2030914 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2030914 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2030914 | http://www.w3.org/2000/01/rdf-schema#comment | "The murine Cas NS-1 retrovirus carries the v-cbl oncogene and induces pre-B cell lymphomas and myeloid leukemias. The cellular homolog of v-cbl has been identified in mouse and human DNA, and was recently mapped to mouse chromosome 9 and human chromosome 11q23. To determine the coding sequences of the human and mouse c-cbl proto-oncogenes cDNA clones were isolated from libraries prepared from the human T cell leukemia lines CCRF-CEM and HUT 78, and the mouse pre-B cell line 70Z/3. DNA sequencing revealed an open reading frame encoding 906 amino acids in the human cDNAs and 896 amino acids in 70Z/3. The sequence showed that v-cbl is a markedly truncated form of murine c-cbl containing 355 N-terminal amino acids. The nucleotide sequence of v-cbl is identical to murine c-cbl in this region, and the human sequence has only five amino acid changes in the v-cbl portion. The most notable features of the sequence which was lost in the generation of v-cbl is a C-terminal leucine zipper and a stretch of 208 amino acids containing 23% proline and 19% serine/threonine residues. This proline-rich sequence has similarities to the transcriptional activation domains of some transcription factors, and v-cbl's transforming potential may be due to the loss of this region and the leucine zipper."xsd:string |
| http://purl.uniprot.org/citations/2030914 | http://purl.uniprot.org/core/author | "Shapiro M."xsd:string |
| http://purl.uniprot.org/citations/2030914 | http://purl.uniprot.org/core/author | "Shapiro M."xsd:string |
| http://purl.uniprot.org/citations/2030914 | http://purl.uniprot.org/core/author | "Langdon W.Y."xsd:string |
| http://purl.uniprot.org/citations/2030914 | http://purl.uniprot.org/core/author | "Langdon W.Y."xsd:string |
| http://purl.uniprot.org/citations/2030914 | http://purl.uniprot.org/core/author | "Morse H.C. III"xsd:string |
| http://purl.uniprot.org/citations/2030914 | http://purl.uniprot.org/core/author | "Morse H.C. III"xsd:string |
| http://purl.uniprot.org/citations/2030914 | http://purl.uniprot.org/core/author | "Blake T.J."xsd:string |
| http://purl.uniprot.org/citations/2030914 | http://purl.uniprot.org/core/author | "Blake T.J."xsd:string |
| http://purl.uniprot.org/citations/2030914 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/2030914 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/2030914 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/2030914 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/2030914 | http://purl.uniprot.org/core/pages | "653-657"xsd:string |
| http://purl.uniprot.org/citations/2030914 | http://purl.uniprot.org/core/pages | "653-657"xsd:string |
| http://purl.uniprot.org/citations/2030914 | http://purl.uniprot.org/core/title | "The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif."xsd:string |
| http://purl.uniprot.org/citations/2030914 | http://purl.uniprot.org/core/title | "The sequences of the human and mouse c-cbl proto-oncogenes show v-cbl was generated by a large truncation encompassing a proline-rich domain and a leucine zipper-like motif."xsd:string |
| http://purl.uniprot.org/citations/2030914 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/2030914 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/2030914 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2030914 |
| http://purl.uniprot.org/citations/2030914 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2030914 |
| http://purl.uniprot.org/citations/2030914 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2030914 |
| http://purl.uniprot.org/citations/2030914 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/2030914 |