| http://purl.uniprot.org/citations/2033035 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/2033035 | http://www.w3.org/2000/01/rdf-schema#comment | "Mitochondrial gene expression has been investigated in synaptic endings from rat cerebral cortex isolated at various stages during the postnatal development and maturation of the animal. The pattern of the mitochondrial translation products labeled in vitro in rat brain synaptosomes revealed some distinctive features when compared with the pattern observed in a rat fibroblast cell line, the most remarkable being the apparent absence of labeling of the ND5 product. This absence contrasted with the presence in synaptosomes of an amount of ND5 mRNA comparable with that found in the rat fibroblast cell line. The rate of mitochondrial protein synthesis per unit amount of mtDNA in brain synaptosomes showed a characteristic reproducible burst at 10-13 days after birth, thereafter declining sharply in the 3rd week to reach a level that remained constant over a 2-year period. The postnatal burst of mitochondrial protein synthesis coincided with a sharp increase in cytochrome c oxidase activity, pointing to a phase of rapid assembly of respiratory complexes. A comparison of the levels of mitochondrial mRNAs with the corresponding rates of protein synthesis during the animal development and maturation showed a lack of correlation. These observations, together with the apparent lack of translation of the ND5 mRNA, indicate that translational control plays a major role in the regulation of gene expression in rat brain synaptic mitochondria."xsd:string |
| http://purl.uniprot.org/citations/2033035 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0021-9258(18)92920-0"xsd:string |
| http://purl.uniprot.org/citations/2033035 | http://purl.uniprot.org/core/author | "Attardi G."xsd:string |
| http://purl.uniprot.org/citations/2033035 | http://purl.uniprot.org/core/author | "Polosa P.L."xsd:string |
| http://purl.uniprot.org/citations/2033035 | http://purl.uniprot.org/core/date | "1991"xsd:gYear |
| http://purl.uniprot.org/citations/2033035 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/2033035 | http://purl.uniprot.org/core/pages | "10011-10017"xsd:string |
| http://purl.uniprot.org/citations/2033035 | http://purl.uniprot.org/core/title | "Distinctive pattern and translational control of mitochondrial protein synthesis in rat brain synaptic endings."xsd:string |
| http://purl.uniprot.org/citations/2033035 | http://purl.uniprot.org/core/volume | "266"xsd:string |
| http://purl.uniprot.org/citations/2033035 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/2033035 |
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| http://purl.uniprot.org/uniprot/#_Q8SEZ0-mappedCitation-2033035 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/2033035 |
| http://purl.uniprot.org/uniprot/P11661 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/2033035 |
| http://purl.uniprot.org/uniprot/Q8SEZ0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/2033035 |