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http://purl.uniprot.org/citations/20332102 | http://www.w3.org/2000/01/rdf-schema#comment | "Canonical Wnt/beta-catenin signaling is crucial during embryonic development. Upon Wnt stimulation, Dishevelled proteins relay the signal from upstream Frizzled receptors to downstream effectors. By using affinity purification followed by ion-trap mass spectrometry we identified K-homology splicing regulator protein (KSRP) as a novel Dishevelled-interacting protein. We show that KSRP negatively regulates Wnt/beta-catenin signaling at the level of post-transcriptional CTNNB1 (beta-catenin) mRNA stability. Thus, Dishevelled-KSRP complex operates in Wnt regulation of beta-catenin, functioning post-transcriptionally upon CTNNB1 mRNA stability."xsd:string |
http://purl.uniprot.org/citations/20332102 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.056176"xsd:string |
http://purl.uniprot.org/citations/20332102 | http://purl.uniprot.org/core/author | "Malbon C.C."xsd:string |
http://purl.uniprot.org/citations/20332102 | http://purl.uniprot.org/core/author | "Bikkavilli R.K."xsd:string |
http://purl.uniprot.org/citations/20332102 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
http://purl.uniprot.org/citations/20332102 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
http://purl.uniprot.org/citations/20332102 | http://purl.uniprot.org/core/pages | "1352-1362"xsd:string |
http://purl.uniprot.org/citations/20332102 | http://purl.uniprot.org/core/title | "Dishevelled-KSRP complex regulates Wnt signaling through post-transcriptional stabilization of beta-catenin mRNA."xsd:string |
http://purl.uniprot.org/citations/20332102 | http://purl.uniprot.org/core/volume | "123"xsd:string |
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