| http://purl.uniprot.org/citations/20335532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20335532 | http://www.w3.org/2000/01/rdf-schema#comment | "Although contact hypersensitivity (CHS) has been considered a prototype of T cell-mediated immune reactions, recently a significant contribution of regulatory B cell subsets in the suppression of CHS has been demonstrated. CD22, one of the sialic acid-binding immunoglobulin-like lectins, is a B cell-specific molecule that negatively regulates BCR signaling. To clarify the roles of B cells in CHS, CHS in CD22(-/-) mice was investigated. CD22(-/-) mice showed delayed recovery from CHS reactions compared with that of wild-type mice. Transfer of wild-type peritoneal B-1a cells reversed the prolonged CHS reaction seen in CD22(-/-) mice, and this was blocked by the simultaneous injection with IL-10 receptor Ab. Although CD22(-/-) peritoneal B-1a cells were capable of producing IL-10 at wild-type levels, i.p. injection of differentially labeled wild-type/CD22(-/-) B cells demonstrated that a smaller number of CD22(-/-) B cells resided in lymphoid organs 5 d after CHS elicitation, suggesting a defect in survival or retention in activated CD22(-/-) peritoneal B-1 cells. Thus, our study reveals a regulatory role for peritoneal B-1a cells in CHS. Two distinct regulatory B cell subsets cooperatively inhibit CHS responses. Although splenic CD1d(hi)CD5(+) B cells have a crucial role in suppressing the acute exacerbating phase of CHS, peritoneal B-1a cells are likely to suppress the late remission phase as "regulatory B cells." CD22 deficiency results in disturbed CHS remission by impaired retention or survival of peritoneal B-1a cells that migrate into lymphoid organs."xsd:string |
| http://purl.uniprot.org/citations/20335532 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0901719"xsd:string |
| http://purl.uniprot.org/citations/20335532 | http://purl.uniprot.org/core/author | "Takahashi Y."xsd:string |
| http://purl.uniprot.org/citations/20335532 | http://purl.uniprot.org/core/author | "Sato S."xsd:string |
| http://purl.uniprot.org/citations/20335532 | http://purl.uniprot.org/core/author | "Tedder T.F."xsd:string |
| http://purl.uniprot.org/citations/20335532 | http://purl.uniprot.org/core/author | "Watanabe R."xsd:string |
| http://purl.uniprot.org/citations/20335532 | http://purl.uniprot.org/core/author | "Fujimoto M."xsd:string |
| http://purl.uniprot.org/citations/20335532 | http://purl.uniprot.org/core/author | "Nakashima H."xsd:string |
| http://purl.uniprot.org/citations/20335532 | http://purl.uniprot.org/core/author | "Hamaguchi Y."xsd:string |
| http://purl.uniprot.org/citations/20335532 | http://purl.uniprot.org/core/author | "Tamaki K."xsd:string |
| http://purl.uniprot.org/citations/20335532 | http://purl.uniprot.org/core/author | "Okochi H."xsd:string |
| http://purl.uniprot.org/citations/20335532 | http://purl.uniprot.org/core/author | "Ishiura N."xsd:string |
| http://purl.uniprot.org/citations/20335532 | http://purl.uniprot.org/core/author | "Kuwano Y."xsd:string |
| http://purl.uniprot.org/citations/20335532 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20335532 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/20335532 | http://purl.uniprot.org/core/pages | "4637-4645"xsd:string |
| http://purl.uniprot.org/citations/20335532 | http://purl.uniprot.org/core/title | "CD22 expression mediates the regulatory functions of peritoneal B-1a cells during the remission phase of contact hypersensitivity reactions."xsd:string |
| http://purl.uniprot.org/citations/20335532 | http://purl.uniprot.org/core/volume | "184"xsd:string |
| http://purl.uniprot.org/citations/20335532 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20335532 |
| http://purl.uniprot.org/citations/20335532 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20335532 |
| http://purl.uniprot.org/uniprot/#_A0A087WQ27-mappedCitation-20335532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20335532 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SSS3-mappedCitation-20335532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20335532 |
| http://purl.uniprot.org/uniprot/#_A0A087WQV3-mappedCitation-20335532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20335532 |
| http://purl.uniprot.org/uniprot/#_A0A087WR31-mappedCitation-20335532 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20335532 |