| http://purl.uniprot.org/citations/20345872 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20345872 | http://www.w3.org/2000/01/rdf-schema#comment | "The pathogenesis of human immunodeficiency virus (HIV) infection clearly involves immunoregulatory host factors and products of major histocompatibility complex class II genes, which present antigenic peptides to the T-cell receptor on CD4+ cells, which in turn increase the production of specific antibodies and cytotoxic T lymphocytes. The main objective of this study was to determine the associations of human leucocyte antigen (HLA) DRB1 and DQB1 alleles and their haplotypes in 210 HIV-1-infected patients and compare them with 129 healthy normal individuals with same ethnic background. The HLA DRB1 and DQB1 alleles were genotyped using polymerase chain reaction product and sequence-specific probes for reverse line hybridization, analysed with the Invitrogen Dynal PMP software. Our results revealed a highly significant increase of HLA DRB1*0902 [odds ratio (OR) = 17.12; P = 0.004], DQB1*030103 (OR = 53.53; P = 4.61E-07) and DQB1*050201 (OR = 16.26; P = 0.0002) alleles while in contrast highly significant decrease in frequency of HLA DQB1*030101 (OR = 0.36; P = 0.0002), DQB1*050301 (OR = 0.22; P < 0.0001) and DQB1*060101 (OR = 0.43; P < 0.0001) among the HIV-1-infected patients when compared with the controls. The haplotype DRB1*0902-DQB1*030103 (OR = 10.65; P = 0.06) was significantly increased in HIV1 patients, while haplotypes DRB1*150101-DQB1*060101 (OR = 0.386, P < 0.0001), DRB1*030101-DQB1*020101 (OR = 0.197, P = 0.004) and DRB1*070101-DQB1*0202 (OR = 0.167, P = 0.001) were significantly decreased. Our results indicate clearly that there are HLA class II alleles involved in the susceptibility to and protection from HIV-1 infection in our study group and further they vary in different ethnic groups reported in literature."xsd:string |
| http://purl.uniprot.org/citations/20345872 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1744-313x.2010.00911.x"xsd:string |
| http://purl.uniprot.org/citations/20345872 | http://purl.uniprot.org/core/author | "Ghosh K."xsd:string |
| http://purl.uniprot.org/citations/20345872 | http://purl.uniprot.org/core/author | "Bajpai S."xsd:string |
| http://purl.uniprot.org/citations/20345872 | http://purl.uniprot.org/core/author | "Pawar A."xsd:string |
| http://purl.uniprot.org/citations/20345872 | http://purl.uniprot.org/core/author | "Shankarkumar U."xsd:string |
| http://purl.uniprot.org/citations/20345872 | http://purl.uniprot.org/core/author | "Pazare A."xsd:string |
| http://purl.uniprot.org/citations/20345872 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20345872 | http://purl.uniprot.org/core/name | "Int J Immunogenet"xsd:string |
| http://purl.uniprot.org/citations/20345872 | http://purl.uniprot.org/core/pages | "199-204"xsd:string |
| http://purl.uniprot.org/citations/20345872 | http://purl.uniprot.org/core/title | "Human leucocyte antigen class II DRB1 and DQB1 associations in human immunodeficiency virus-infected patients of Mumbai, India."xsd:string |
| http://purl.uniprot.org/citations/20345872 | http://purl.uniprot.org/core/volume | "37"xsd:string |
| http://purl.uniprot.org/citations/20345872 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20345872 |
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