Results

RDF/XMLNTriplesTurtleShow queryShare ▶
SubjectPredicateObject
http://purl.uniprot.org/citations/20345939http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20345939http://www.w3.org/2000/01/rdf-schema#comment"Carbamazepine (CBZ) has been reported as the most common culprit drug for Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in several Asian countries including Thailand. A strong association between HLA-B*1502 and CBZ-induced SJS/TEN has been reported in Han Chinese but not in Caucasian and Japanese populations. A case-control study was conducted to determine whether HLA-B*1502 is a valid pharmacogenetic test for SJS/TEN caused by CBZ in a Thai population. Among 42 CBZ-induced patients with SJS/TEN, 37 (88.10%) patients carried the HLA-B*1502 while only 5 (11.90%) of the CBZ-tolerant controls had this allele. The risk of CBZ-induced SJS/TEN was significantly higher in the patients with HLA-B*1502, with an odds ratio (OR) of 54.76 [95% confidence interval (CI) 14.62-205.13, p = 2.89 x 10(-12)]. The sensitivity and specificity of HLA-B*1502 for prediction of CBZ-induced SJS/TEN were 88.10%. By assuming a 0.27% as a prevalence rate of CBZ-induced SJS/TEN in a Thai population, the positive predictive value (PPV) and negative predictive value (NPV) of the HLA-B*1502 were 1.92% and 99.96%. Results from this study suggest that HLA-B*1502 may be a useful pharmacogenetic test for screening Thai individuals who may be at risk for CBZ-induced SJS and TEN."xsd:string
http://purl.uniprot.org/citations/20345939http://purl.org/dc/terms/identifier"doi:10.1111/j.1528-1167.2010.02533.x"xsd:string
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/author"Chen W.H."xsd:string
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/author"Chen P."xsd:string
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/author"Lin S.Y."xsd:string
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/author"Tassaneeyakul W."xsd:string
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/author"Choonhakarn C."xsd:string
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/author"Pongpakdee S."xsd:string
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/author"Jantararoungtong T."xsd:string
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/author"Khunarkornsiri U."xsd:string
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/author"Konyoung P."xsd:string
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/author"Tiamkao S."xsd:string
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/author"Aungaree T."xsd:string
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/author"Auvichayapat N."xsd:string
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/author"Kulkantrakorn K."xsd:string
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/author"Pavakul K."xsd:string
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/author"Phonhiamhan S."xsd:string
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/author"Piyatrakul N."xsd:string
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/author"Yodnopaglaw P."xsd:string
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/name"Epilepsia"xsd:string
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/pages"926-930"xsd:string
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/title"Association between HLA-B*1502 and carbamazepine-induced severe cutaneous adverse drug reactions in a Thai population."xsd:string
http://purl.uniprot.org/citations/20345939http://purl.uniprot.org/core/volume"51"xsd:string
▶