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http://purl.uniprot.org/citations/20346027http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20346027http://www.w3.org/2000/01/rdf-schema#comment"

Background

Basal cell carcinoma (BCC) is 10 times more frequent in organ transplant recipients (OTRs) than in the general population. Factors in OTRs conferring increased susceptibility to BCC include ultraviolet radiation exposure, immunosuppression, viral infections such as human papillomavirus, phototype and genetic predisposition. The PTCH1 gene is a negative regulator of the hedgehog pathway, that provides mitogenic signals to basal cells in skin. PTCH1 gene mutations cause naevoid BCC syndrome, and contribute to the development of sporadic BCC and other types of cancers. Associations have been reported between PTCH1 polymorphisms and BCC susceptibility in nontransplanted individuals.

Objectives

To search for novel common polymorphisms in the proximal 5' regulatory region upstream of PTCH1 gene exon 1B, and to investigate the possible association of PTCH1 polymorphisms and haplotypes with BCC risk after organ transplantation.

Methods

Three PTCH1 single nucleotide polymorphisms (rs2297086, rs2066836 and rs357564) were analysed by restriction fragment length polymorphism analysis in 161 northern Italian OTRs (56 BCC cases and 105 controls). Two regions of the PTCH1 gene promoter were screened by heteroduplex analysis in 30 cases and 30 controls.

Results

Single locus analysis showed no significant association. Haplotype T(1686)-T(3944) appeared to confer a significantly higher risk for BCC development (odds ratio 2.98, 95% confidence interval 2.55-3.48; P = 0.001). Two novel rare polymorphisms were identified at positions 176 and 179 of the 5'UTR. Two novel alleles of the -4 (CGG)(n) microsatellite were identified. No association of this microsatellite with BCC was observed.

Conclusions

Haplotypes containing T(1686)-T(3944) alleles were shown to be associated with an increased BCC risk in our study population. These data appear to be of great interest for further investigations in a larger group of transplant individuals. Our results do not support the hypothesis that common polymorphisms in the proximal 5' regulatory region of the PTCH1 gene could represent an important risk factor for BCC after organ transplantation."xsd:string
http://purl.uniprot.org/citations/20346027http://purl.org/dc/terms/identifier"doi:10.1111/j.1365-2133.2010.09776.x"xsd:string
http://purl.uniprot.org/citations/20346027http://purl.uniprot.org/core/author"Gomez Lira M."xsd:string
http://purl.uniprot.org/citations/20346027http://purl.uniprot.org/core/author"Girolomoni G."xsd:string
http://purl.uniprot.org/citations/20346027http://purl.uniprot.org/core/author"Cascone C."xsd:string
http://purl.uniprot.org/citations/20346027http://purl.uniprot.org/core/author"Malerba G."xsd:string
http://purl.uniprot.org/citations/20346027http://purl.uniprot.org/core/author"Turco A."xsd:string
http://purl.uniprot.org/citations/20346027http://purl.uniprot.org/core/author"Boschiero L."xsd:string
http://purl.uniprot.org/citations/20346027http://purl.uniprot.org/core/author"Fortina A.B."xsd:string
http://purl.uniprot.org/citations/20346027http://purl.uniprot.org/core/author"Forni A."xsd:string
http://purl.uniprot.org/citations/20346027http://purl.uniprot.org/core/author"Naldi L."xsd:string
http://purl.uniprot.org/citations/20346027http://purl.uniprot.org/core/author"Piaserico S."xsd:string
http://purl.uniprot.org/citations/20346027http://purl.uniprot.org/core/author"Rugiu C."xsd:string
http://purl.uniprot.org/citations/20346027http://purl.uniprot.org/core/author"Tessari G."xsd:string
http://purl.uniprot.org/citations/20346027http://purl.uniprot.org/core/author"Gotti E."xsd:string
http://purl.uniprot.org/citations/20346027http://purl.uniprot.org/core/author"Begnini A."xsd:string
http://purl.uniprot.org/citations/20346027http://purl.uniprot.org/core/author"Brunello A."xsd:string
http://purl.uniprot.org/citations/20346027http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20346027http://purl.uniprot.org/core/name"Br J Dermatol"xsd:string
http://purl.uniprot.org/citations/20346027http://purl.uniprot.org/core/pages"364-370"xsd:string
http://purl.uniprot.org/citations/20346027http://purl.uniprot.org/core/title"PTCH1 gene haplotype association with basal cell carcinoma after transplantation."xsd:string
http://purl.uniprot.org/citations/20346027http://purl.uniprot.org/core/volume"163"xsd:string
http://purl.uniprot.org/citations/20346027http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20346027
http://purl.uniprot.org/citations/20346027http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20346027
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