| http://purl.uniprot.org/citations/20347965 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20347965 | http://www.w3.org/2000/01/rdf-schema#comment | "Neurotrophin-induced Trk tyrosine kinase receptor activation and neuronal cell survival responses have been reported to be under the control of a membrane associated sialidase. Here, we identify an unprecedented membrane sialidase mechanism initiated by nerve growth factor (NGF) binding to TrkA to potentiate GPCR-signaling via membrane Galphai subunit proteins and matrix metalloproteinase-9 (MMP-9) activation to induce Neu1 sialidase activation in live primary neurons and TrkA- and TrkB-expressing cell lines. Central to this process is that Neu1/MMP-9 complex is bound to TrkA on the cell surface of naïve primary neurons and TrkA-expressing cells. Tamiflu completely blocks this sialidase activity in live TrkA-PC12 cells treated with NGF with an IC(50) of 3.876 microM with subsequent inhibition of Trk activation in primary neurons and neurite outgrowth in TrkA-PC12 cells. Our findings uncover a Neu1 and MMP-9 cross-talk on the cell surface that is critically essential for neurotrophin-induced Trk tyrosine kinase receptor activation and cellular signaling."xsd:string |
| http://purl.uniprot.org/citations/20347965 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cellsig.2010.03.011"xsd:string |
| http://purl.uniprot.org/citations/20347965 | http://purl.uniprot.org/core/author | "Gee K."xsd:string |
| http://purl.uniprot.org/citations/20347965 | http://purl.uniprot.org/core/author | "Amith S.R."xsd:string |
| http://purl.uniprot.org/citations/20347965 | http://purl.uniprot.org/core/author | "Jayanth P."xsd:string |
| http://purl.uniprot.org/citations/20347965 | http://purl.uniprot.org/core/author | "Szewczuk M.R."xsd:string |
| http://purl.uniprot.org/citations/20347965 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20347965 | http://purl.uniprot.org/core/name | "Cell Signal"xsd:string |
| http://purl.uniprot.org/citations/20347965 | http://purl.uniprot.org/core/pages | "1193-1205"xsd:string |
| http://purl.uniprot.org/citations/20347965 | http://purl.uniprot.org/core/title | "Neu1 sialidase and matrix metalloproteinase-9 cross-talk is essential for neurotrophin activation of Trk receptors and cellular signaling."xsd:string |
| http://purl.uniprot.org/citations/20347965 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/20347965 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20347965 |
| http://purl.uniprot.org/citations/20347965 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20347965 |
| http://purl.uniprot.org/uniprot/Q99PW3#attribution-1C057C8BF5549A33383D62A44396D59F | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20347965 |
| http://purl.uniprot.org/uniprot/Q99PW3#attribution-66D23DEA8D704998608A03185989FCC5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20347965 |
| http://purl.uniprot.org/uniprot/#_Q6MG70-mappedCitation-20347965 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20347965 |
| http://purl.uniprot.org/uniprot/#_Q99PW3-mappedCitation-20347965 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20347965 |
| http://purl.uniprot.org/uniprot/Q6MG70 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20347965 |
| http://purl.uniprot.org/uniprot/Q99PW3 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20347965 |