| http://purl.uniprot.org/citations/20351107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20351107 | http://www.w3.org/2000/01/rdf-schema#comment | "Interferon regulatory factors (IRFs) are crucial for transcription during innate immune responses. We have previously shown that the tyrosine kinase c-Src enhances IRF-3-dependent transcription in response to viral double-stranded RNA. In this study, we show that c-Src has distinct roles in Toll-like receptor (TLR)-mediated activation of IRF-5 and IRF-3. Surprisingly, c-Src inhibition markedly enhanced IRF-5 activation after treatment with unmethylated CpG, while suppressing IRF-3 activation. Also, CpG-elicited interleukin-6 mRNA production was increased, whereas IP10 mRNA synthesis was reduced in cells deficient in c-Src. Interestingly, c-Src regulated TLR-stimulated induction of activating transcription factor 3 (ATF3), a transcriptional repressor. Depletion of ATF3 by small interfering RNA markedly enhanced interleukin-6 production after CpG treatment, whereas IP10 production was reduced. These results demonstrate functional specificity for c-Src in TLR-stimulated responses and suggest that c-Src modulation and ATF3 activity may contribute to differential regulation of IRF-3- versus IRF-5-mediated gene expression."xsd:string |
| http://purl.uniprot.org/citations/20351107 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.068817"xsd:string |
| http://purl.uniprot.org/citations/20351107 | http://purl.uniprot.org/core/author | "Nguyen T.T."xsd:string |
| http://purl.uniprot.org/citations/20351107 | http://purl.uniprot.org/core/author | "Fitzgerald K.A."xsd:string |
| http://purl.uniprot.org/citations/20351107 | http://purl.uniprot.org/core/author | "Lien E."xsd:string |
| http://purl.uniprot.org/citations/20351107 | http://purl.uniprot.org/core/author | "Anthonsen M.W."xsd:string |
| http://purl.uniprot.org/citations/20351107 | http://purl.uniprot.org/core/author | "Johnsen I.B."xsd:string |
| http://purl.uniprot.org/citations/20351107 | http://purl.uniprot.org/core/author | "Drablos F."xsd:string |
| http://purl.uniprot.org/citations/20351107 | http://purl.uniprot.org/core/author | "Knetter C.F."xsd:string |
| http://purl.uniprot.org/citations/20351107 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20351107 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20351107 | http://purl.uniprot.org/core/pages | "17011-17019"xsd:string |
| http://purl.uniprot.org/citations/20351107 | http://purl.uniprot.org/core/title | "Differential gene expression downstream of Toll-like receptors (TLRs): role of c-Src and activating transcription factor 3 (ATF3)."xsd:string |
| http://purl.uniprot.org/citations/20351107 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/20351107 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20351107 |
| http://purl.uniprot.org/citations/20351107 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20351107 |
| http://purl.uniprot.org/uniprot/#_E2GIM5-mappedCitation-20351107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20351107 |
| http://purl.uniprot.org/uniprot/#_E2GIM6-mappedCitation-20351107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20351107 |
| http://purl.uniprot.org/uniprot/#_E2GIM7-mappedCitation-20351107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20351107 |
| http://purl.uniprot.org/uniprot/#_E2GIM8-mappedCitation-20351107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20351107 |
| http://purl.uniprot.org/uniprot/#_E2GIM9-mappedCitation-20351107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20351107 |
| http://purl.uniprot.org/uniprot/#_P56477-mappedCitation-20351107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20351107 |
| http://purl.uniprot.org/uniprot/#_P70671-mappedCitation-20351107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20351107 |
| http://purl.uniprot.org/uniprot/#_A0A0G2UM11-mappedCitation-20351107 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20351107 |