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http://purl.uniprot.org/citations/20351547http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20351547http://www.w3.org/2000/01/rdf-schema#comment"

Background and objective

DNA repair capacity is correlated with sensitivity of cancer cells toward platinum-based chemotherapy. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) in polymorphisms of DNA repair gene ERCC1 (excision repair cross-complementation group 1) and XPD (ERCC2, excision repair cross-complementation group 2) were associated with the tumor response in advanced non-small-cell lung cancer (NSCLC) patients received platinum-based chemotherapy in Chinese population.

Methods

Totally 115 patients with advanced NSCLC were routinely treated with cisplatin- or carboplatin-based chemotherapy, and clinical response was evaluated after 2 cycles. Three dimensions (3-D) polyacrylamide gel-based DNA microarray method was used to evaluate the genotypes of ERCC1 Asn118Asn (354 CT), Gln504Lys (8092 CA) and XPD Lys751Gln (35931 AC).

Results

The C→T change of ERCC1 Asn118Asn polymorphism and the C→A change of ERCC1 Gln504Lys polymorphism have statistically significant association with elevated or descendent platinum-based chemotherapy response respectively.

Conclusion

The polymorphic status of ERCC1 might be the promising ancillary marker for predicting treatment response of advanced stage NSCLC patients. The DNA microarray-based method is accurate, high-throughput and inexpensive, suitable for SNP genotyping in a large number of individuals."xsd:string
http://purl.uniprot.org/citations/20351547http://purl.org/dc/terms/identifier"doi:10.1097/coc.0b013e3181b9cedc"xsd:string
http://purl.uniprot.org/citations/20351547http://purl.uniprot.org/core/author"Cheng H."xsd:string
http://purl.uniprot.org/citations/20351547http://purl.uniprot.org/core/author"Chen B."xsd:string
http://purl.uniprot.org/citations/20351547http://purl.uniprot.org/core/author"Cheng L."xsd:string
http://purl.uniprot.org/citations/20351547http://purl.uniprot.org/core/author"Ji J."xsd:string
http://purl.uniprot.org/citations/20351547http://purl.uniprot.org/core/author"Li F."xsd:string
http://purl.uniprot.org/citations/20351547http://purl.uniprot.org/core/author"Lu Z."xsd:string
http://purl.uniprot.org/citations/20351547http://purl.uniprot.org/core/author"Sun X."xsd:string
http://purl.uniprot.org/citations/20351547http://purl.uniprot.org/core/author"Qin S."xsd:string
http://purl.uniprot.org/citations/20351547http://purl.uniprot.org/core/author"Zhou Y."xsd:string
http://purl.uniprot.org/citations/20351547http://purl.uniprot.org/core/author"Feng J."xsd:string
http://purl.uniprot.org/citations/20351547http://purl.uniprot.org/core/author"Sun N."xsd:string
http://purl.uniprot.org/citations/20351547http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20351547http://purl.uniprot.org/core/name"Am J Clin Oncol"xsd:string
http://purl.uniprot.org/citations/20351547http://purl.uniprot.org/core/pages"489-494"xsd:string
http://purl.uniprot.org/citations/20351547http://purl.uniprot.org/core/title"Association between polymorphisms of ERCC1 and XPD and clinical response to platinum-based chemotherapy in advanced non-small cell lung cancer."xsd:string
http://purl.uniprot.org/citations/20351547http://purl.uniprot.org/core/volume"33"xsd:string
http://purl.uniprot.org/citations/20351547http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20351547
http://purl.uniprot.org/citations/20351547http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20351547
http://purl.uniprot.org/uniprot/#_A0A1B1PFW1-mappedCitation-20351547http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20351547
http://purl.uniprot.org/uniprot/#_A0A2S1WCK5-mappedCitation-20351547http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20351547
http://purl.uniprot.org/uniprot/#_B4E0F6-mappedCitation-20351547http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20351547
http://purl.uniprot.org/uniprot/#_P18074-mappedCitation-20351547http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20351547
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