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http://purl.uniprot.org/citations/20352323http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
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Purpose

To investigate the expression pattern of the SEPT7 protein during spermatogenesis and its potential role in sperm function.

Methods

We first investigated the expression pattern of SEPT7 during different steps of mouse spermiogenesis using an immunofluorescence assay (IFA). IFA was also applied to study the expression pattern of SEPT7 in human ejaculated spermatozoa. Nine fertile men with normal semen parameters were used as the control group, and 21 infertile men with asthenozoospermia were recruited as the patient group. We assessed the frequency of the SEPT7 signal in the various morphological subgroups.

Results

In humans, the frequency of a defective SEPT7 signal was significantly increased in men with asthenozoospermia. The absence of a SEPT7 signal was more prevalent in sperm containing morphological defects of various types.

Conclusions

The expression pattern of SEPT7 suggested that this protein may be involved in the regulation of subcellular-compartment formation during spermiogenesis in the mouse. The absence of a SEPT7 signal correlated with multiple sperm defects."xsd:string
http://purl.uniprot.org/citations/20352323http://purl.org/dc/terms/identifier"doi:10.1007/s10815-010-9409-4"xsd:string
http://purl.uniprot.org/citations/20352323http://purl.uniprot.org/core/author"Lin Y.H."xsd:string
http://purl.uniprot.org/citations/20352323http://purl.uniprot.org/core/author"Kuo P.L."xsd:string
http://purl.uniprot.org/citations/20352323http://purl.uniprot.org/core/author"Kuo Y.C."xsd:string
http://purl.uniprot.org/citations/20352323http://purl.uniprot.org/core/author"Pan H.A."xsd:string
http://purl.uniprot.org/citations/20352323http://purl.uniprot.org/core/author"Shen C.J."xsd:string
http://purl.uniprot.org/citations/20352323http://purl.uniprot.org/core/author"Chao H.C."xsd:string
http://purl.uniprot.org/citations/20352323http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20352323http://purl.uniprot.org/core/name"J Assist Reprod Genet"xsd:string
http://purl.uniprot.org/citations/20352323http://purl.uniprot.org/core/pages"299-307"xsd:string
http://purl.uniprot.org/citations/20352323http://purl.uniprot.org/core/title"The expression pattern of SEPT7 correlates with sperm morphology."xsd:string
http://purl.uniprot.org/citations/20352323http://purl.uniprot.org/core/volume"27"xsd:string
http://purl.uniprot.org/citations/20352323http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20352323
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