| http://purl.uniprot.org/citations/20353815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20353815 | http://www.w3.org/2000/01/rdf-schema#comment | "Ritonavir is a protease inhibitor associated with metabolic abnormalities and cardiovascular disease. We have investigated the effects of low-dose ritonavir treatment on gene expression in peripheral blood mononuclear cells (PBMC) of 10 healthy donors. Results using whole genome Illumina microarrays show that ritonavir modulates a number of genes implicated in lipid metabolism, inflammation and atherosclerosis. These candidate genes are dual specificity phosphatase 1 DUSP1), Kelch domain containing 3 (KLHDC3), neutral cholesterol ester hydrolase 1 (NCEH1) and acyl-CoA synthetase short-chain family member 2 (ACSS2). Validation experiments using quantitative PCR showed that ritonavir (at 100 mg once daily and 100 mg twice daily significantly down-regulated these 4 selected candidate genes in 20 healthy individuals. Lower expression levels of these 4 candidate genes, known to play a critical role in inflammation, lipid metabolism and atherosclerosis, may explain ritonavir adverse effects in patients."xsd:string |
| http://purl.uniprot.org/citations/20353815 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.ygeno.2010.03.011"xsd:string |
| http://purl.uniprot.org/citations/20353815 | http://purl.uniprot.org/core/author | "Fletcher C."xsd:string |
| http://purl.uniprot.org/citations/20353815 | http://purl.uniprot.org/core/author | "Yilmaz S."xsd:string |
| http://purl.uniprot.org/citations/20353815 | http://purl.uniprot.org/core/author | "McGregor J.L."xsd:string |
| http://purl.uniprot.org/citations/20353815 | http://purl.uniprot.org/core/author | "Waters L."xsd:string |
| http://purl.uniprot.org/citations/20353815 | http://purl.uniprot.org/core/author | "Pozniak A."xsd:string |
| http://purl.uniprot.org/citations/20353815 | http://purl.uniprot.org/core/author | "Gazzard B."xsd:string |
| http://purl.uniprot.org/citations/20353815 | http://purl.uniprot.org/core/author | "Collot-Teixeira S."xsd:string |
| http://purl.uniprot.org/citations/20353815 | http://purl.uniprot.org/core/author | "Back D."xsd:string |
| http://purl.uniprot.org/citations/20353815 | http://purl.uniprot.org/core/author | "De Lorenzo F."xsd:string |
| http://purl.uniprot.org/citations/20353815 | http://purl.uniprot.org/core/author | "Boffito M."xsd:string |
| http://purl.uniprot.org/citations/20353815 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20353815 | http://purl.uniprot.org/core/name | "Genomics"xsd:string |
| http://purl.uniprot.org/citations/20353815 | http://purl.uniprot.org/core/pages | "57-65"xsd:string |
| http://purl.uniprot.org/citations/20353815 | http://purl.uniprot.org/core/title | "Investigation of low-dose ritonavir on human peripheral blood mononuclear cells using gene expression whole genome microarrays."xsd:string |
| http://purl.uniprot.org/citations/20353815 | http://purl.uniprot.org/core/volume | "96"xsd:string |
| http://purl.uniprot.org/citations/20353815 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20353815 |
| http://purl.uniprot.org/citations/20353815 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20353815 |
| http://purl.uniprot.org/uniprot/#_A0A0A0MTJ9-mappedCitation-20353815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20353815 |
| http://purl.uniprot.org/uniprot/#_A8K1K0-mappedCitation-20353815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20353815 |
| http://purl.uniprot.org/uniprot/#_A0A384MTJ4-mappedCitation-20353815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20353815 |
| http://purl.uniprot.org/uniprot/#_B4DU40-mappedCitation-20353815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20353815 |
| http://purl.uniprot.org/uniprot/#_B4DQ64-mappedCitation-20353815 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20353815 |