| http://purl.uniprot.org/citations/20353996 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20353996 | http://www.w3.org/2000/01/rdf-schema#comment | "The TAF4b subunit of the transcription factor IID, which has a central role in transcription by polymerase II, is involved in promoter recognition by selective recruitment of activators. The activating protein-1 (AP-1) family members participate in oncogenic transformation via gene regulation. Utilizing immunoprecipitation of endogenous protein complexes, we documented specific interactions between Jun family members and TATA box binding protein-associated factors (TAF) in colon HT29 adenocarcinoma cells. Particularly, TAF4b and c-Jun were found to colocalize and interact in the nucleus of advanced carcinoma cells and in cells with epithelial-to-mesenchymal transition (EMT) characteristics. TAF4b was found to specifically regulate the AP-1 target gene involved in EMT integrin alpha6, thus altering related cellular properties such as migration potential. Using a chromatin immunoprecipitation approach in colon adenocarcinoma cell lines, we further identified a synergistic role for TAF4b and c-Jun and other AP-1 family members on the promoter of integrin alpha6, underlining the existence of a specific mechanism related to gene expression control. We show evidence for the first time of an interdependence of TAF4b and AP-1 family members in cell type-specific promoter recognition and initiation of transcription in the context of cancer progression and EMT."xsd:string |
| http://purl.uniprot.org/citations/20353996 | http://purl.org/dc/terms/identifier | "doi:10.1158/1541-7786.mcr-09-0159"xsd:string |
| http://purl.uniprot.org/citations/20353996 | http://purl.uniprot.org/core/author | "Davidson I."xsd:string |
| http://purl.uniprot.org/citations/20353996 | http://purl.uniprot.org/core/author | "Kostourou V."xsd:string |
| http://purl.uniprot.org/citations/20353996 | http://purl.uniprot.org/core/author | "Tora L."xsd:string |
| http://purl.uniprot.org/citations/20353996 | http://purl.uniprot.org/core/author | "Sandaltzopoulos R."xsd:string |
| http://purl.uniprot.org/citations/20353996 | http://purl.uniprot.org/core/author | "Dikstein R."xsd:string |
| http://purl.uniprot.org/citations/20353996 | http://purl.uniprot.org/core/author | "Pintzas A."xsd:string |
| http://purl.uniprot.org/citations/20353996 | http://purl.uniprot.org/core/author | "Kalogeropoulou M."xsd:string |
| http://purl.uniprot.org/citations/20353996 | http://purl.uniprot.org/core/author | "Voulgari A."xsd:string |
| http://purl.uniprot.org/citations/20353996 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20353996 | http://purl.uniprot.org/core/name | "Mol Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/20353996 | http://purl.uniprot.org/core/pages | "554-568"xsd:string |
| http://purl.uniprot.org/citations/20353996 | http://purl.uniprot.org/core/title | "TAF4b and Jun/activating protein-1 collaborate to regulate the expression of integrin alpha6 and cancer cell migration properties."xsd:string |
| http://purl.uniprot.org/citations/20353996 | http://purl.uniprot.org/core/volume | "8"xsd:string |
| http://purl.uniprot.org/citations/20353996 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20353996 |
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