| http://purl.uniprot.org/citations/20357242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20357242 | http://www.w3.org/2000/01/rdf-schema#comment | "Fatty acid metabolism governs multiple intracellular signaling pathways in many cell types, but its role in hematopoietic stem cells (HSCs) is largely unknown. Herein, we establish a critical role for 12/15-lipoxygenase (12/15-LOX)-mediated unsaturated fatty acid metabolism in HSC function. HSCs from 12/15-LOX-deficient mice are severely compromised in their capacity to reconstitute the hematopoietic compartment in competitive and serial reconstitution assays. Furthermore, we demonstrate that 12/15-LOX is required for the maintenance of long-term HSC quiescence and number. The defect in HSCs is cell-autonomous and associated with a selective reduction in 12/15-LOX-mediated generation of bioactive lipid mediators and reactive oxygen species and with a decrease in canonical Wnt signaling as measured by nuclear beta-catenin staining. These results have implications for development, aging, and transformation of the hematopoietic compartment."xsd:string |
| http://purl.uniprot.org/citations/20357242 | http://purl.org/dc/terms/identifier | "doi:10.1182/blood-2009-09-243139"xsd:string |
| http://purl.uniprot.org/citations/20357242 | http://purl.uniprot.org/core/author | "Zhao L."xsd:string |
| http://purl.uniprot.org/citations/20357242 | http://purl.uniprot.org/core/author | "Wei C."xsd:string |
| http://purl.uniprot.org/citations/20357242 | http://purl.uniprot.org/core/author | "Blair I.A."xsd:string |
| http://purl.uniprot.org/citations/20357242 | http://purl.uniprot.org/core/author | "Kundu M."xsd:string |
| http://purl.uniprot.org/citations/20357242 | http://purl.uniprot.org/core/author | "Kinder M."xsd:string |
| http://purl.uniprot.org/citations/20357242 | http://purl.uniprot.org/core/author | "Pure E."xsd:string |
| http://purl.uniprot.org/citations/20357242 | http://purl.uniprot.org/core/author | "Shelat S.G."xsd:string |
| http://purl.uniprot.org/citations/20357242 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20357242 | http://purl.uniprot.org/core/name | "Blood"xsd:string |
| http://purl.uniprot.org/citations/20357242 | http://purl.uniprot.org/core/pages | "5012-5022"xsd:string |
| http://purl.uniprot.org/citations/20357242 | http://purl.uniprot.org/core/title | "Hematopoietic stem cell function requires 12/15-lipoxygenase-dependent fatty acid metabolism."xsd:string |
| http://purl.uniprot.org/citations/20357242 | http://purl.uniprot.org/core/volume | "115"xsd:string |
| http://purl.uniprot.org/citations/20357242 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20357242 |
| http://purl.uniprot.org/citations/20357242 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20357242 |
| http://purl.uniprot.org/uniprot/#_A2CF88-mappedCitation-20357242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20357242 |
| http://purl.uniprot.org/uniprot/#_P39654-mappedCitation-20357242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20357242 |
| http://purl.uniprot.org/uniprot/P39654 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20357242 |
| http://purl.uniprot.org/uniprot/A2CF88 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20357242 |