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| http://purl.uniprot.org/citations/20359850 | http://www.w3.org/2000/01/rdf-schema#comment | "Oxidative stress can contribute to the development of hepatocellular carcinoma (HCC) ability of the carcinoma. It has been found that oxidative stress stimulates the phosphorylation of eIF4E primarily through mitogen-activated protein kinase (MAPK) pathways resulting in increased protein translation. Utilizing specific inhibitors of MAPK pathways (SP600125 for c-Jun amino-terminal kinases [JNKs], PD098059 for extracellular signal-regulated kinases [ERKs], and SB203580 for p38 MAPK), we determined that it is primarily the inhibition of JNK that results in the suppression of the increase of p-eIF4E. We also found that PDCD4 inhibits JNK activity resulting in inhibition of the phosphorylation of c-Jun, one isoform of AP-1. We demonstrated that transfection with PDCD4 or inhibition of JNK by SP600125 alters the expression and phosphorylation of eIF4E in the presence of H(2)O(2). PDCD4 results in a stronger inhibitory effect than SP600125."xsd:string |
| http://purl.uniprot.org/citations/20359850 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.biopha.2010.01.015"xsd:string |
| http://purl.uniprot.org/citations/20359850 | http://purl.uniprot.org/core/author | "Jiang Y."xsd:string |
| http://purl.uniprot.org/citations/20359850 | http://purl.uniprot.org/core/author | "Zhang S.H."xsd:string |
| http://purl.uniprot.org/citations/20359850 | http://purl.uniprot.org/core/author | "Han G.Q."xsd:string |
| http://purl.uniprot.org/citations/20359850 | http://purl.uniprot.org/core/author | "Qin C.Y."xsd:string |
| http://purl.uniprot.org/citations/20359850 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20359850 | http://purl.uniprot.org/core/name | "Biomed Pharmacother"xsd:string |
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| http://purl.uniprot.org/citations/20359850 | http://purl.uniprot.org/core/title | "Interaction of Pdcd4 with eIF4E inhibits the metastatic potential of hepatocellular carcinoma."xsd:string |
| http://purl.uniprot.org/citations/20359850 | http://purl.uniprot.org/core/volume | "64"xsd:string |
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