| http://purl.uniprot.org/citations/20360400 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20360400 | http://www.w3.org/2000/01/rdf-schema#comment | "IL-7R, FLT3, and CD43 are surface antigens expressed during the transition from pro-B to pre-B cells in BM. To understand interactions between their signaling pathways, we analyzed spontaneous mouse B-LBLs with dual MLV integration into Stat5a and Fiz1 or Stat5a and Hipk2. MLV integration resulted in up-regulation of these genes in lymphoma cells compared with normal pro-B cells from the BM. In lymphomas with both integrations into Stat5a and Fiz1, increases in phosphorylated STAT5A and expression of c-Myc, a target gene of STAT5A, were observed following stimulation of the FLT3. Clones with the dual integrations grew faster in IL-7 and FLT3L-supplemented medium than clones with Stat5a integration alone. On the other hand, in lymphomas with integrations into Stat5a and Hipk2, increases in phosphorylated STAT5A and expression of c-Myc were observed following cross-linking of CD43. In conclusion, FLT3 and CD43 signaling pathways involve STAT5A via Fiz1 and Hipk2 in B-LBLs. Identification of the dual MLV integration sites in B-LBLs, therefore, will provide an excellent tool for identification of the signaling pathways in B-LBLs."xsd:string |
| http://purl.uniprot.org/citations/20360400 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.1109748"xsd:string |
| http://purl.uniprot.org/citations/20360400 | http://purl.uniprot.org/core/author | "Imai Y."xsd:string |
| http://purl.uniprot.org/citations/20360400 | http://purl.uniprot.org/core/author | "Nakamura T."xsd:string |
| http://purl.uniprot.org/citations/20360400 | http://purl.uniprot.org/core/author | "Okuno T."xsd:string |
| http://purl.uniprot.org/citations/20360400 | http://purl.uniprot.org/core/author | "Maruyama Y."xsd:string |
| http://purl.uniprot.org/citations/20360400 | http://purl.uniprot.org/core/author | "Takeuchi H."xsd:string |
| http://purl.uniprot.org/citations/20360400 | http://purl.uniprot.org/core/author | "Hiratsuka T."xsd:string |
| http://purl.uniprot.org/citations/20360400 | http://purl.uniprot.org/core/author | "Ozeki M."xsd:string |
| http://purl.uniprot.org/citations/20360400 | http://purl.uniprot.org/core/author | "Jin G."xsd:string |
| http://purl.uniprot.org/citations/20360400 | http://purl.uniprot.org/core/author | "Manabe T."xsd:string |
| http://purl.uniprot.org/citations/20360400 | http://purl.uniprot.org/core/author | "Tamaki K."xsd:string |
| http://purl.uniprot.org/citations/20360400 | http://purl.uniprot.org/core/author | "Hiai H."xsd:string |
| http://purl.uniprot.org/citations/20360400 | http://purl.uniprot.org/core/author | "Kanaya K."xsd:string |
| http://purl.uniprot.org/citations/20360400 | http://purl.uniprot.org/core/author | "Takakuwa T."xsd:string |
| http://purl.uniprot.org/citations/20360400 | http://purl.uniprot.org/core/author | "Tsuruyama T."xsd:string |
| http://purl.uniprot.org/citations/20360400 | http://purl.uniprot.org/core/author | "Kaszynski R."xsd:string |
| http://purl.uniprot.org/citations/20360400 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20360400 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/20360400 | http://purl.uniprot.org/core/pages | "107-116"xsd:string |
| http://purl.uniprot.org/citations/20360400 | http://purl.uniprot.org/core/title | "Dual retrovirus integration tagging: identification of new signaling molecules Fiz1 and Hipk2 that are involved in the IL-7 signaling pathway in B lymphoblastic lymphomas."xsd:string |
| http://purl.uniprot.org/citations/20360400 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/20360400 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20360400 |
| http://purl.uniprot.org/citations/20360400 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20360400 |