| http://purl.uniprot.org/citations/20360404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20360404 | http://www.w3.org/2000/01/rdf-schema#comment | "Recently, it has been shown that certain combinations of TLR ligands act in synergy to induce the release of IL-12 by DCs. In this study, we sought to define the critical parameters underlying TLR synergy. Our data show that TLR ligands act synergistically if MyD88- and TRIF-dependent ligands are combined. TLR4 uses both of these adaptor molecules, thus activation via TLR4 proved to be a synergistic event on its own. TLR synergy did not affect all aspects of DC activation but enhanced primarily the release of certain cytokines, particularly IL-12, whereas the expression of costimulatory molecules remained unchanged. Consequently, synergistic activation of DC did not affect their ability to induce T cell proliferation but resulted in T(H)1-biased responses in vitro and in vivo. Furthermore, we examined the impact of TLR ligand combinations on primary DC in vitro but observed only modest effects with a combination of CpG + Poly (I:C). However, noticeable synergy in terms of IL-12 production by DCs was detectable in vivo after systemic administration of CpG + Poly (I:C). Finally, we show that synergy is partially dependent on IFNAR signaling but does not require the release of IFNs to the enviroment, suggesting an autocrine action of type I IFNs."xsd:string |
| http://purl.uniprot.org/citations/20360404 | http://purl.org/dc/terms/identifier | "doi:10.1189/jlb.0408228"xsd:string |
| http://purl.uniprot.org/citations/20360404 | http://purl.uniprot.org/core/author | "Shen L."xsd:string |
| http://purl.uniprot.org/citations/20360404 | http://purl.uniprot.org/core/author | "Heinz S."xsd:string |
| http://purl.uniprot.org/citations/20360404 | http://purl.uniprot.org/core/author | "Grabbe S."xsd:string |
| http://purl.uniprot.org/citations/20360404 | http://purl.uniprot.org/core/author | "Balkow S."xsd:string |
| http://purl.uniprot.org/citations/20360404 | http://purl.uniprot.org/core/author | "Probst H.C."xsd:string |
| http://purl.uniprot.org/citations/20360404 | http://purl.uniprot.org/core/author | "Krummen M."xsd:string |
| http://purl.uniprot.org/citations/20360404 | http://purl.uniprot.org/core/author | "Loquai C."xsd:string |
| http://purl.uniprot.org/citations/20360404 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20360404 | http://purl.uniprot.org/core/name | "J Leukoc Biol"xsd:string |
| http://purl.uniprot.org/citations/20360404 | http://purl.uniprot.org/core/pages | "189-199"xsd:string |
| http://purl.uniprot.org/citations/20360404 | http://purl.uniprot.org/core/title | "Release of IL-12 by dendritic cells activated by TLR ligation is dependent on MyD88 signaling, whereas TRIF signaling is indispensable for TLR synergy."xsd:string |
| http://purl.uniprot.org/citations/20360404 | http://purl.uniprot.org/core/volume | "88"xsd:string |
| http://purl.uniprot.org/citations/20360404 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20360404 |
| http://purl.uniprot.org/citations/20360404 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20360404 |
| http://purl.uniprot.org/uniprot/#_Q0PM15-mappedCitation-20360404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20360404 |
| http://purl.uniprot.org/uniprot/#_Q0PM16-mappedCitation-20360404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20360404 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLE4-mappedCitation-20360404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20360404 |
| http://purl.uniprot.org/uniprot/#_A0A338P6T9-mappedCitation-20360404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20360404 |
| http://purl.uniprot.org/uniprot/#_A0A338P6X7-mappedCitation-20360404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20360404 |
| http://purl.uniprot.org/uniprot/#_A0A384DVB8-mappedCitation-20360404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20360404 |
| http://purl.uniprot.org/uniprot/#_A0A1S5WLF0-mappedCitation-20360404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20360404 |
| http://purl.uniprot.org/uniprot/#_A2AHJ1-mappedCitation-20360404 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20360404 |