| http://purl.uniprot.org/citations/20360684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20360684 | http://www.w3.org/2000/01/rdf-schema#comment | "Upon infection with many RNA viruses, the cytoplasmic retinoic acid inducible gene-I (RIG-I) pathway activates the latent transcription factor IRF-3, causing its nuclear translocation and the induction of many antiviral genes, including those encoding interferons. Here, we report a novel and distinct activity of IRF-3, in virus-infected cells, that induces apoptosis. Using genetically defective mouse and human cell lines, we demonstrated that, although both pathways required the presence of RIG-I, IPS1, TRAF3 and TBK1, only the apoptotic pathway required the presence of TRAF2 and TRAF6 in addition. More importantly, transcriptionally inactive IRF-3 mutants, such as the one missing its DNA-binding domain, could efficiently mediate apoptosis. Apoptosis was triggered by the direct interaction of IRF-3, through a newly identified BH3 domain, with the pro-apoptotic protein Bax, their co-translocation to the mitochondria and the resulting activation of the mitochondrial apoptotic pathway. Thus, IRF-3 is a dual-action cytoplasmic protein that, upon activation, translocates to the nucleus or to the mitochondrion and triggers two complementary antiviral responses of the infected cell."xsd:string |
| http://purl.uniprot.org/citations/20360684 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2010.50"xsd:string |
| http://purl.uniprot.org/citations/20360684 | http://purl.uniprot.org/core/author | "Desai A."xsd:string |
| http://purl.uniprot.org/citations/20360684 | http://purl.uniprot.org/core/author | "Yamashita M."xsd:string |
| http://purl.uniprot.org/citations/20360684 | http://purl.uniprot.org/core/author | "Smith K."xsd:string |
| http://purl.uniprot.org/citations/20360684 | http://purl.uniprot.org/core/author | "Chattopadhyay S."xsd:string |
| http://purl.uniprot.org/citations/20360684 | http://purl.uniprot.org/core/author | "Sen G.C."xsd:string |
| http://purl.uniprot.org/citations/20360684 | http://purl.uniprot.org/core/author | "Marques J.T."xsd:string |
| http://purl.uniprot.org/citations/20360684 | http://purl.uniprot.org/core/author | "Williams B.R."xsd:string |
| http://purl.uniprot.org/citations/20360684 | http://purl.uniprot.org/core/author | "Peters K.L."xsd:string |
| http://purl.uniprot.org/citations/20360684 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20360684 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/20360684 | http://purl.uniprot.org/core/pages | "1762-1773"xsd:string |
| http://purl.uniprot.org/citations/20360684 | http://purl.uniprot.org/core/title | "Viral apoptosis is induced by IRF-3-mediated activation of Bax."xsd:string |
| http://purl.uniprot.org/citations/20360684 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/20360684 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20360684 |
| http://purl.uniprot.org/citations/20360684 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20360684 |
| http://purl.uniprot.org/uniprot/#_E2GIM5-mappedCitation-20360684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20360684 |
| http://purl.uniprot.org/uniprot/#_E2GIM6-mappedCitation-20360684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20360684 |
| http://purl.uniprot.org/uniprot/#_E2GIM7-mappedCitation-20360684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20360684 |
| http://purl.uniprot.org/uniprot/#_E2GIM8-mappedCitation-20360684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20360684 |
| http://purl.uniprot.org/uniprot/#_E2GIM9-mappedCitation-20360684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20360684 |
| http://purl.uniprot.org/uniprot/#_P70671-mappedCitation-20360684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20360684 |
| http://purl.uniprot.org/uniprot/#_Q07812-mappedCitation-20360684 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20360684 |