DESCRIBE <http://purl.uniprot.org/citations/20367881>

Subject	Predicate	Object
http://purl.uniprot.org/citations/20367881	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20367881	http://www.w3.org/2000/01/rdf-schema#comment	" Background Following entry, uncoating, and reverse transcription, a number of cellular proteins become associated with the human immunodeficiency virus type 1 (HIV-1) pre-integration complex (PIC). With the goal of obtaining reagents for the analysis of the HIV-1 PIC composition and localisation, we have constructed functional integrase (IN) and matrix (MA) proteins that can be biotinylated during virus production and captured using streptavidin-coated beads. Results Although the labelled C-terminus allows for the sensitive detection of virion-associated IN, it becomes inaccessible in the presence of cellular proteins. This masking is not dependent on the nature of the tag and does not occur with the tagged MA. It was not observed either with an IN mutant unable to interact with LEDGF/p75, or when LEDGF/p75 was depleted from cells. Conclusion Our observation suggests that a structural rearrangement or oligomerization of the IN protein occurs during the early steps of infection and that this process is related to the presence of LEDGF/p75."xsd:string
http://purl.uniprot.org/citations/20367881	http://purl.org/dc/terms/identifier	"doi:10.1186/1742-4690-7-27"xsd:string
http://purl.uniprot.org/citations/20367881	http://purl.uniprot.org/core/author	"Danos O."xsd:string
http://purl.uniprot.org/citations/20367881	http://purl.uniprot.org/core/author	"Bucher S."xsd:string
http://purl.uniprot.org/citations/20367881	http://purl.uniprot.org/core/author	"Benkhelifa-Ziyyat S."xsd:string
http://purl.uniprot.org/citations/20367881	http://purl.uniprot.org/core/author	"Pasquet J."xsd:string
http://purl.uniprot.org/citations/20367881	http://purl.uniprot.org/core/author	"Zanta-Boussif M.A."xsd:string
http://purl.uniprot.org/citations/20367881	http://purl.uniprot.org/core/date	"2010"xsd:gYear
http://purl.uniprot.org/citations/20367881	http://purl.uniprot.org/core/name	"Retrovirology"xsd:string
http://purl.uniprot.org/citations/20367881	http://purl.uniprot.org/core/pages	"27"xsd:string
http://purl.uniprot.org/citations/20367881	http://purl.uniprot.org/core/title	"Changes in the accessibility of the HIV-1 Integrase C-terminus in the presence of cellular proteins."xsd:string
http://purl.uniprot.org/citations/20367881	http://purl.uniprot.org/core/volume	"7"xsd:string
http://purl.uniprot.org/citations/20367881	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/20367881
http://purl.uniprot.org/citations/20367881	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/20367881
http://purl.uniprot.org/uniprot/#_Q05CM9-mappedCitation-20367881	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/20367881
http://purl.uniprot.org/uniprot/#_L8E926-mappedCitation-20367881	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/20367881
http://purl.uniprot.org/uniprot/#_Q8N4N4-mappedCitation-20367881	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/20367881
http://purl.uniprot.org/uniprot/#_O75475-mappedCitation-20367881	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/20367881
http://purl.uniprot.org/uniprot/#_P04585-mappedCitation-20367881	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/20367881
http://purl.uniprot.org/uniprot/P04585	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/20367881
http://purl.uniprot.org/uniprot/Q8N4N4	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/20367881
http://purl.uniprot.org/uniprot/O75475	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/20367881
http://purl.uniprot.org/uniprot/Q05CM9	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/20367881
http://purl.uniprot.org/uniprot/L8E926	http://purl.uniprot.org/core/mappedCitation	http://purl.uniprot.org/citations/20367881