| http://purl.uniprot.org/citations/20368287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20368287 | http://www.w3.org/2000/01/rdf-schema#comment | "The phosphatidylinositol 3-kinase-mammalian target of rapamycin (PI3K-mTOR) pathway plays pivotal roles in cell survival, growth, and proliferation downstream of growth factors. Its perturbations are associated with cancer progression, type 2 diabetes, and neurological disorders. To better understand the mechanisms of action and regulation of this pathway, we initiated a large scale yeast two-hybrid screen for 33 components of the PI3K-mTOR pathway. Identification of 67 new interactions was followed by validation by co-affinity purification and exhaustive literature curation of existing information. We provide a nearly complete, functionally annotated interactome of 802 interactions for the PI3K-mTOR pathway. Our screen revealed a predominant place for glycogen synthase kinase-3 (GSK3) A and B and the AMP-activated protein kinase. In particular, we identified the deformed epidermal autoregulatory factor-1 (DEAF1) transcription factor as an interactor and in vitro substrate of GSK3A and GSK3B. Moreover, GSK3 inhibitors increased DEAF1 transcriptional activity on the 5-HT1A serotonin receptor promoter. We propose that DEAF1 may represent a therapeutic target of lithium and other GSK3 inhibitors used in bipolar disease and depression."xsd:string |
| http://purl.uniprot.org/citations/20368287 | http://purl.org/dc/terms/identifier | "doi:10.1074/mcp.m900568-mcp200"xsd:string |
| http://purl.uniprot.org/citations/20368287 | http://purl.uniprot.org/core/author | "Brun C."xsd:string |
| http://purl.uniprot.org/citations/20368287 | http://purl.uniprot.org/core/author | "Vidal M."xsd:string |
| http://purl.uniprot.org/citations/20368287 | http://purl.uniprot.org/core/author | "Hill D.E."xsd:string |
| http://purl.uniprot.org/citations/20368287 | http://purl.uniprot.org/core/author | "Cusick M.E."xsd:string |
| http://purl.uniprot.org/citations/20368287 | http://purl.uniprot.org/core/author | "Goillot E."xsd:string |
| http://purl.uniprot.org/citations/20368287 | http://purl.uniprot.org/core/author | "Schaeffer L."xsd:string |
| http://purl.uniprot.org/citations/20368287 | http://purl.uniprot.org/core/author | "Robinson-Rechavi M."xsd:string |
| http://purl.uniprot.org/citations/20368287 | http://purl.uniprot.org/core/author | "Rual J.F."xsd:string |
| http://purl.uniprot.org/citations/20368287 | http://purl.uniprot.org/core/author | "Chopin E."xsd:string |
| http://purl.uniprot.org/citations/20368287 | http://purl.uniprot.org/core/author | "Pilot-Storck F."xsd:string |
| http://purl.uniprot.org/citations/20368287 | http://purl.uniprot.org/core/author | "Baudot A."xsd:string |
| http://purl.uniprot.org/citations/20368287 | http://purl.uniprot.org/core/author | "Dobrokhotov P."xsd:string |
| http://purl.uniprot.org/citations/20368287 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20368287 | http://purl.uniprot.org/core/name | "Mol Cell Proteomics"xsd:string |
| http://purl.uniprot.org/citations/20368287 | http://purl.uniprot.org/core/pages | "1578-1593"xsd:string |
| http://purl.uniprot.org/citations/20368287 | http://purl.uniprot.org/core/title | "Interactome mapping of the phosphatidylinositol 3-kinase-mammalian target of rapamycin pathway identifies deformed epidermal autoregulatory factor-1 as a new glycogen synthase kinase-3 interactor."xsd:string |
| http://purl.uniprot.org/citations/20368287 | http://purl.uniprot.org/core/volume | "9"xsd:string |
| http://purl.uniprot.org/citations/20368287 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20368287 |
| http://purl.uniprot.org/citations/20368287 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20368287 |
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| http://purl.uniprot.org/uniprot/#_Q14232-mappedCitation-20368287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20368287 |
| http://purl.uniprot.org/uniprot/#_Q15654-mappedCitation-20368287 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20368287 |