| http://purl.uniprot.org/citations/20368359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20368359 | http://www.w3.org/2000/01/rdf-schema#comment | "Genetic programs that govern neural stem/progenitor cell (NSC) proliferation and differentiation are dependent on extracellular cues and a network of transcription factors, which can be regulated posttranslationally by phosphorylation. However, little is known about the kinase-dependent pathways regulating NSC maintenance and oligodendrocyte development. We used a conditional knockout approach to target the murine regulatory subunit (beta) of protein kinase casein kinase 2 (CK2beta) in embryonic neural progenitors. Loss of CK2beta leads to defects in proliferation and differentiation of embryonic NSCs. We establish CK2beta as a key positive regulator for the development of oligodendrocyte precursor cells (OPCs), both in vivo and in vitro. We show that CK2beta directly interacts with the basic helix-loop-helix (bHLH) transcription factor Olig2, a critical modulator of OPC development, and activates the CK2-dependent phosphorylation of its serine-threonine-rich (STR) domain. Finally, we reveal that the CK2-targeted STR domain is required for the oligodendroglial function of Olig2. These findings suggest that CK2 may control oligodendrogenesis, in part, by regulating the activity of the lineage-specific transcription factor Olig2. Thus, CK2beta appears to play an essential and uncompensated role in central nervous system development."xsd:string |
| http://purl.uniprot.org/citations/20368359 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01566-09"xsd:string |
| http://purl.uniprot.org/citations/20368359 | http://purl.uniprot.org/core/author | "Wong M."xsd:string |
| http://purl.uniprot.org/citations/20368359 | http://purl.uniprot.org/core/author | "Cochet C."xsd:string |
| http://purl.uniprot.org/citations/20368359 | http://purl.uniprot.org/core/author | "Baudier J."xsd:string |
| http://purl.uniprot.org/citations/20368359 | http://purl.uniprot.org/core/author | "Buchou T."xsd:string |
| http://purl.uniprot.org/citations/20368359 | http://purl.uniprot.org/core/author | "Deloulme J.C."xsd:string |
| http://purl.uniprot.org/citations/20368359 | http://purl.uniprot.org/core/author | "Souchelnytskyi S."xsd:string |
| http://purl.uniprot.org/citations/20368359 | http://purl.uniprot.org/core/author | "Huillard E."xsd:string |
| http://purl.uniprot.org/citations/20368359 | http://purl.uniprot.org/core/author | "Blond O."xsd:string |
| http://purl.uniprot.org/citations/20368359 | http://purl.uniprot.org/core/author | "Ziercher L."xsd:string |
| http://purl.uniprot.org/citations/20368359 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20368359 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/20368359 | http://purl.uniprot.org/core/pages | "2737-2749"xsd:string |
| http://purl.uniprot.org/citations/20368359 | http://purl.uniprot.org/core/title | "Disruption of CK2beta in embryonic neural stem cells compromises proliferation and oligodendrogenesis in the mouse telencephalon."xsd:string |
| http://purl.uniprot.org/citations/20368359 | http://purl.uniprot.org/core/volume | "30"xsd:string |
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| http://purl.uniprot.org/uniprot/#_A0A0J9YV87-mappedCitation-20368359 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20368359 |