| http://purl.uniprot.org/citations/20368431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20368431 | http://www.w3.org/2000/01/rdf-schema#comment | "Neuronal growth cones are highly motile structures that tip developing neurites and explore their surroundings before axo-dendritic contact and synaptogenesis. However, the membrane proteins organizing these processes remain insufficiently understood. Here we identify that the synaptic cell adhesion molecule 1 (SynCAM 1), an immunoglobulin superfamily member, is already expressed in developing neurons and localizes to their growth cones. Upon interaction of growth cones with target neurites, SynCAM 1 rapidly assembles at these contacts to form stable adhesive clusters. Synaptic markers can also be detected at these sites. Addressing the functions of SynCAM 1 in growth cones preceding contact, we determine that it is required and sufficient to restrict the number of active filopodia. Further, SynCAM 1 negatively regulates the morphological complexity of migrating growth cones. Focal adhesion kinase, a binding partner of SynCAM 1, is implicated in its morphogenetic activities. These results reveal that SynCAM 1 acts in developing neurons to shape migrating growth cones and contributes to the adhesive differentiation of their axo-dendritic contacts."xsd:string |
| http://purl.uniprot.org/citations/20368431 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0911798107"xsd:string |
| http://purl.uniprot.org/citations/20368431 | http://purl.uniprot.org/core/author | "Stagi M."xsd:string |
| http://purl.uniprot.org/citations/20368431 | http://purl.uniprot.org/core/author | "Fogel A.I."xsd:string |
| http://purl.uniprot.org/citations/20368431 | http://purl.uniprot.org/core/author | "Biederer T."xsd:string |
| http://purl.uniprot.org/citations/20368431 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20368431 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/20368431 | http://purl.uniprot.org/core/pages | "7568-7573"xsd:string |
| http://purl.uniprot.org/citations/20368431 | http://purl.uniprot.org/core/title | "SynCAM 1 participates in axo-dendritic contact assembly and shapes neuronal growth cones."xsd:string |
| http://purl.uniprot.org/citations/20368431 | http://purl.uniprot.org/core/volume | "107"xsd:string |
| http://purl.uniprot.org/citations/20368431 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20368431 |
| http://purl.uniprot.org/citations/20368431 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20368431 |
| http://purl.uniprot.org/uniprot/#_A0A1L1SS08-mappedCitation-20368431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20368431 |
| http://purl.uniprot.org/uniprot/#_E0CY16-mappedCitation-20368431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20368431 |
| http://purl.uniprot.org/uniprot/#_A0A668KLV1-mappedCitation-20368431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20368431 |
| http://purl.uniprot.org/uniprot/#_B5L830-mappedCitation-20368431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20368431 |
| http://purl.uniprot.org/uniprot/#_B5L831-mappedCitation-20368431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20368431 |
| http://purl.uniprot.org/uniprot/#_B5L832-mappedCitation-20368431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20368431 |
| http://purl.uniprot.org/uniprot/#_B5L833-mappedCitation-20368431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20368431 |
| http://purl.uniprot.org/uniprot/#_B5L834-mappedCitation-20368431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20368431 |
| http://purl.uniprot.org/uniprot/#_E9PYN1-mappedCitation-20368431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20368431 |
| http://purl.uniprot.org/uniprot/#_Q1WIL9-mappedCitation-20368431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20368431 |
| http://purl.uniprot.org/uniprot/#_Q9QYL3-mappedCitation-20368431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20368431 |
| http://purl.uniprot.org/uniprot/#_Q9QYL4-mappedCitation-20368431 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20368431 |