| http://purl.uniprot.org/citations/20375757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20375757 | http://www.w3.org/2000/01/rdf-schema#comment | "ObjectivesHLA-B*5701 is a major histocompatibility complex class I allele associated with an immunologically-mediated hypersensitivity reaction to abacavir. The objectives of this study were to evaluate HLA-B*5701 prevalence among European, HIV-1-infected patients and to compare the local and central laboratory screening results.MethodsData were combined from six multicentre, prospective studies involving 10 European countries in which HIV-1-infected patients (irrespective of treatment experience or previous HLA-B*5701 screening), >or=18 years of age, were evaluated for HLA-B*5701 carriage, determined by the central and local laboratory methods.ResultsA total of 9720 patients from 272 centres were included in the analysis. The overall estimate of HLA-B*5701 prevalence in Europe was 4.98%, with country-specific estimates ranging from 1.53 to 7.75%. HLA-B*5701 prevalence was highest in the self-reported white population (6.49%) and lowest in the black population (0.39%). Local laboratory results had a high specificity (99.9%) and sensitivity (99.2%) when compared with the central laboratory results.ConclusionThis study supports data from previous studies regarding the prevalence of HLA-B*5701 in the HIV population and the variation of HLA-B*5701 prevalence between different racial groups. The high specificity and sensitivity of local laboratory results, suggests that clinicians can be confident in using local laboratories for pretreatment HLA-B*5701 screening. However, it is essential that local laboratories participate in HLA-B*5701-specific quality assurance programs to maintain 100% sensitivity. In HIV-infected patients, pretreatment HLA-B*5701 screening may allow more informed decisions regarding abacavir use and has the potential to significantly reduce the frequency of abacavir-related hypersensitivity reactions and costs associated with managing these reactions."xsd:string |
| http://purl.uniprot.org/citations/20375757 | http://purl.org/dc/terms/identifier | "doi:10.1097/fpc.0b013e3283390666"xsd:string |
| http://purl.uniprot.org/citations/20375757 | http://purl.uniprot.org/core/author | "Wang J."xsd:string |
| http://purl.uniprot.org/citations/20375757 | http://purl.uniprot.org/core/author | "Molina J.M."xsd:string |
| http://purl.uniprot.org/citations/20375757 | http://purl.uniprot.org/core/author | "Bergin C."xsd:string |
| http://purl.uniprot.org/citations/20375757 | http://purl.uniprot.org/core/author | "Pearce H."xsd:string |
| http://purl.uniprot.org/citations/20375757 | http://purl.uniprot.org/core/author | "Cavassini M."xsd:string |
| http://purl.uniprot.org/citations/20375757 | http://purl.uniprot.org/core/author | "Esser S."xsd:string |
| http://purl.uniprot.org/citations/20375757 | http://purl.uniprot.org/core/author | "Lazzarin A."xsd:string |
| http://purl.uniprot.org/citations/20375757 | http://purl.uniprot.org/core/author | "Orkin C."xsd:string |
| http://purl.uniprot.org/citations/20375757 | http://purl.uniprot.org/core/author | "Gomez Sirvent J.L."xsd:string |
| http://purl.uniprot.org/citations/20375757 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20375757 | http://purl.uniprot.org/core/name | "Pharmacogenet Genomics"xsd:string |
| http://purl.uniprot.org/citations/20375757 | http://purl.uniprot.org/core/pages | "307-314"xsd:string |
| http://purl.uniprot.org/citations/20375757 | http://purl.uniprot.org/core/title | "An epidemiologic study to determine the prevalence of the HLA-B*5701 allele among HIV-positive patients in Europe."xsd:string |
| http://purl.uniprot.org/citations/20375757 | http://purl.uniprot.org/core/volume | "20"xsd:string |
| http://purl.uniprot.org/citations/20375757 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20375757 |
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| http://purl.uniprot.org/uniprot/#_A0A0E3DCA1-mappedCitation-20375757 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20375757 |
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