| http://purl.uniprot.org/citations/20376080 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20376080 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcription factor CCAAT enhancer-binding protein alpha (C/EBPalpha) has an important role in granulopoiesis. The tumor suppressor function of C/EBPalpha is shown by the findings that loss of expression or function of C/EBPalpha in leukemic blasts contributes to a block in myeloid cell differentiation and to leukemia. C/EBPalpha mutations are found in around 9% of acute myeloid leukemia (AML) patients. The mechanism by which the mutant form of C/EBPalpha (C/EBPalpha-p30) exerts a differentiation block is not well understood. By using a proteomic screen, we have recently reported PIN1 as a target of C/EBPalpha-p30 in AML. In the present study, we show that C/EBPalpha-p30 induces PIN1 expression. We observed elevated PIN1 expression in leukemic patient samples. Induction of C/EBPalpha-p30 results in recruitment of E2F1 in the PIN1 promoter. We show that the inhibition of PIN1 leads to myeloid differentiation in primary AML blasts with C/EBPalpha mutations. Overexpression of PIN1 in myeloid cells leads to block of granulocyte differentiation. We also show that PIN1 increases the stability of the c-Jun protein by inhibiting c-Jun ubiquitination, and c-Jun blocks granulocyte differentiation mediated by C/EBPalpha. Our data suggest that the inhibition of PIN1 could be a potential strategy of treating AML patients with C/EBPalpha mutation."xsd:string |
| http://purl.uniprot.org/citations/20376080 | http://purl.org/dc/terms/identifier | "doi:10.1038/leu.2010.37"xsd:string |
| http://purl.uniprot.org/citations/20376080 | http://purl.uniprot.org/core/author | "Ryo A."xsd:string |
| http://purl.uniprot.org/citations/20376080 | http://purl.uniprot.org/core/author | "Tenen D.G."xsd:string |
| http://purl.uniprot.org/citations/20376080 | http://purl.uniprot.org/core/author | "Bohlander S.K."xsd:string |
| http://purl.uniprot.org/citations/20376080 | http://purl.uniprot.org/core/author | "Behre G."xsd:string |
| http://purl.uniprot.org/citations/20376080 | http://purl.uniprot.org/core/author | "Kawasaki A."xsd:string |
| http://purl.uniprot.org/citations/20376080 | http://purl.uniprot.org/core/author | "Geletu M."xsd:string |
| http://purl.uniprot.org/citations/20376080 | http://purl.uniprot.org/core/author | "Pulikkan J.A."xsd:string |
| http://purl.uniprot.org/citations/20376080 | http://purl.uniprot.org/core/author | "Peer Zada A.A."xsd:string |
| http://purl.uniprot.org/citations/20376080 | http://purl.uniprot.org/core/author | "Dengler V."xsd:string |
| http://purl.uniprot.org/citations/20376080 | http://purl.uniprot.org/core/author | "Pasalic Z."xsd:string |
| http://purl.uniprot.org/citations/20376080 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20376080 | http://purl.uniprot.org/core/name | "Leukemia"xsd:string |
| http://purl.uniprot.org/citations/20376080 | http://purl.uniprot.org/core/pages | "914-923"xsd:string |
| http://purl.uniprot.org/citations/20376080 | http://purl.uniprot.org/core/title | "Elevated PIN1 expression by C/EBPalpha-p30 blocks C/EBPalpha-induced granulocytic differentiation through c-Jun in AML."xsd:string |
| http://purl.uniprot.org/citations/20376080 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/20376080 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20376080 |
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| http://purl.uniprot.org/uniprot/Q49AR7 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20376080 |