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http://purl.uniprot.org/citations/20378848http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20378848http://www.w3.org/2000/01/rdf-schema#comment"

Objective

The metabolic and genetic correlates of circulating insulin-like growth factor-1 (IGF-1) and its main circulating carrier, IGF-1-binding-protein-3 (IGFBP-3), are unclear.

Methods and results

We measured serum IGF-1 and IGFBP-3 concentrations in a sample of the Framingham Heart Study (N=3977, aged 40+/-9 years, 46% male) and evaluated their relations to cardiovascular risk factors using multivariable regression. Serum IGF-1 was inversely correlated with age, body mass index, total cholesterol, the presence of diabetes, alcohol consumption, and glomerular filtration rate (all P<0.01), whereas the ratio of IGF-1:IGFBP-3 was lower in women and inversely related to age, triglycerides, high-density lipoprotein cholesterol, systolic blood pressure, and alcohol consumption (all P<0.0001). Circulating IGF-1 correlated negatively with insulin resistance (homeostatic model assessment) (r=-0.1; P<0.0001) and was lower in participants with more components of the metabolic syndrome (Adult Treatment Panel III criteria) (P<0.0001). Additive genetic factors (heritability) accounted for 43% and 39% of the variation of IGF-1 and IGFBP-3, respectively (both P<10(-27)).

Conclusions

Our cross-sectional observations in a large community-based sample link lower circulating IGF-1 to greater metabolic risk burden and underscore substantial genetic influences on IGF-1 concentrations. Prospective studies are warranted to elucidate whether lower IGF-1 concentrations predict greater metabolic risk longitudinally."xsd:string
http://purl.uniprot.org/citations/20378848http://purl.org/dc/terms/identifier"doi:10.1161/atvbaha.110.203943"xsd:string
http://purl.uniprot.org/citations/20378848http://purl.uniprot.org/core/author"Peng X."xsd:string
http://purl.uniprot.org/citations/20378848http://purl.uniprot.org/core/author"Yang Q."xsd:string
http://purl.uniprot.org/citations/20378848http://purl.uniprot.org/core/author"Lam C.S."xsd:string
http://purl.uniprot.org/citations/20378848http://purl.uniprot.org/core/author"Chen M.H."xsd:string
http://purl.uniprot.org/citations/20378848http://purl.uniprot.org/core/author"Smith H.M."xsd:string
http://purl.uniprot.org/citations/20378848http://purl.uniprot.org/core/author"Sawyer D.B."xsd:string
http://purl.uniprot.org/citations/20378848http://purl.uniprot.org/core/author"Sullivan L.M."xsd:string
http://purl.uniprot.org/citations/20378848http://purl.uniprot.org/core/author"Vasan R.S."xsd:string
http://purl.uniprot.org/citations/20378848http://purl.uniprot.org/core/author"Safa R."xsd:string
http://purl.uniprot.org/citations/20378848http://purl.uniprot.org/core/author"Xanthakis V."xsd:string
http://purl.uniprot.org/citations/20378848http://purl.uniprot.org/core/author"Lacey S.M."xsd:string
http://purl.uniprot.org/citations/20378848http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20378848http://purl.uniprot.org/core/name"Arterioscler Thromb Vasc Biol"xsd:string
http://purl.uniprot.org/citations/20378848http://purl.uniprot.org/core/pages"1479-1484"xsd:string
http://purl.uniprot.org/citations/20378848http://purl.uniprot.org/core/title"Circulating insulin-like growth factor-1 and its binding protein-3: metabolic and genetic correlates in the community."xsd:string
http://purl.uniprot.org/citations/20378848http://purl.uniprot.org/core/volume"30"xsd:string
http://purl.uniprot.org/citations/20378848http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20378848
http://purl.uniprot.org/citations/20378848http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20378848
http://purl.uniprot.org/uniprot/#_B3KRZ1-mappedCitation-20378848http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20378848
http://purl.uniprot.org/uniprot/#_B3KRJ8-mappedCitation-20378848http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20378848
http://purl.uniprot.org/uniprot/#_B3KVF9-mappedCitation-20378848http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20378848
http://purl.uniprot.org/uniprot/#_A6XNC9-mappedCitation-20378848http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20378848
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