| http://purl.uniprot.org/citations/20385769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20385769 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20385769 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies revealed that a class III semaphorin, semaphorin 3E (Sema3E), acts through a single-pass transmembrane receptor, plexin D1, to provide a repulsive cue for plexin D1-expressing endothelial cells, thus providing a highly conserved and developmentally regulated signaling system guiding the growth of blood vessels. We show here that Sema3E acts as a potent inhibitor of adult and tumor-induced angiogenesis. Activation of plexin D1 by Sema3E causes the rapid disassembly of integrin-mediated adhesive structures, thereby inhibiting endothelial cell adhesion to the extracellular matrix (ECM) and causing the retraction of filopodia in endothelial tip cells. Sema3E acts on plexin D1 to initiate a two-pronged mechanism involving R-Ras inactivation and Arf6 stimulation, which affect the status of activation of integrins and their intracellular trafficking, respectively. Ultimately, our present study provides a molecular framework for antiangiogenesis signaling, thus impinging on a myriad of pathological conditions that are characterized by aberrant increase in neovessel formation, including cancer."xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01652-09"xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01652-09"xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.uniprot.org/core/author | "Li X."xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.uniprot.org/core/author | "Zhang F."xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.uniprot.org/core/author | "Zhang F."xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.uniprot.org/core/author | "Sakurai A."xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.uniprot.org/core/author | "Sakurai A."xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.uniprot.org/core/author | "Randazzo P.A."xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.uniprot.org/core/author | "Randazzo P.A."xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.uniprot.org/core/author | "Gutkind J.S."xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.uniprot.org/core/author | "Gutkind J.S."xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.uniprot.org/core/author | "Yagi H."xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.uniprot.org/core/author | "Yagi H."xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.uniprot.org/core/author | "Weigert R."xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.uniprot.org/core/author | "Weigert R."xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.uniprot.org/core/author | "Amornphimoltham P."xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.uniprot.org/core/author | "Amornphimoltham P."xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.uniprot.org/core/author | "Annas-Linhares Y."xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.uniprot.org/core/author | "Annas-Linhares Y."xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.uniprot.org/core/author | "Basile J.R."xsd:string |
| http://purl.uniprot.org/citations/20385769 | http://purl.uniprot.org/core/author | "Basile J.R."xsd:string |