| http://purl.uniprot.org/citations/20385772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20385772 | http://www.w3.org/2000/01/rdf-schema#comment | "Lipin 1 is a bifunctional protein that regulates gene transcription and, as a Mg(2+)-dependent phosphatidic acid phosphatase (PAP), is a key enzyme in the biosynthesis of phospholipids and triacylglycerol. We describe here the functional interaction between lipin 1 and the nuclear factor of activated T cells c4 (NFATc4). Lipin 1 represses NFATc4 transcriptional activity through protein-protein interaction, and lipin 1 is present at the promoters of NFATc4 transcriptional targets in vivo. Catalytically active and inactive lipin 1 can suppress NFATc4 transcriptional activity, and this suppression may involve recruitment of histone deacetylases to target promoters. In fat pads from mice deficient for lipin 1 (fld mice) and in 3T3-L1 adipocytes depleted of lipin 1 there is increased expression of several NFAT target genes including tumor necrosis factor alpha, resistin, FABP4, and PPARgamma. Finally, both lipin 1 protein and total PAP activity are decreased with increasing adiposity in the visceral, but not subcutaneous, fat pads of ob/ob mice. These observations place lipin 1 as a potentially important link between triacylglycerol synthesis and adipose tissue inflammation."xsd:string |
| http://purl.uniprot.org/citations/20385772 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.01671-09"xsd:string |
| http://purl.uniprot.org/citations/20385772 | http://purl.uniprot.org/core/author | "Kumar A."xsd:string |
| http://purl.uniprot.org/citations/20385772 | http://purl.uniprot.org/core/author | "Wang L."xsd:string |
| http://purl.uniprot.org/citations/20385772 | http://purl.uniprot.org/core/author | "Lawrence J.C. Jr."xsd:string |
| http://purl.uniprot.org/citations/20385772 | http://purl.uniprot.org/core/author | "Liu G.H."xsd:string |
| http://purl.uniprot.org/citations/20385772 | http://purl.uniprot.org/core/author | "Harris T.E."xsd:string |
| http://purl.uniprot.org/citations/20385772 | http://purl.uniprot.org/core/author | "Keller S.R."xsd:string |
| http://purl.uniprot.org/citations/20385772 | http://purl.uniprot.org/core/author | "Kim H.B."xsd:string |
| http://purl.uniprot.org/citations/20385772 | http://purl.uniprot.org/core/author | "Finck B.N."xsd:string |
| http://purl.uniprot.org/citations/20385772 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20385772 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/20385772 | http://purl.uniprot.org/core/pages | "3126-3139"xsd:string |
| http://purl.uniprot.org/citations/20385772 | http://purl.uniprot.org/core/title | "Lipin 1 represses NFATc4 transcriptional activity in adipocytes to inhibit secretion of inflammatory factors."xsd:string |
| http://purl.uniprot.org/citations/20385772 | http://purl.uniprot.org/core/volume | "30"xsd:string |
| http://purl.uniprot.org/citations/20385772 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20385772 |
| http://purl.uniprot.org/citations/20385772 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20385772 |
| http://purl.uniprot.org/uniprot/Q91ZP3#attribution-05A8F9771AD8433E432CCDB7CC02F690 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20385772 |
| http://purl.uniprot.org/uniprot/Q91ZP3#attribution-D7CF88981DC56874BF1A1E181E1480C9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20385772 |
| http://purl.uniprot.org/uniprot/Q8K120#attribution-05A8F9771AD8433E432CCDB7CC02F690 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20385772 |
| http://purl.uniprot.org/uniprot/P23204#attribution-05A8F9771AD8433E432CCDB7CC02F690 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20385772 |
| http://purl.uniprot.org/uniprot/#_A0A0G2JGG3-mappedCitation-20385772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20385772 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRR0-mappedCitation-20385772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20385772 |
| http://purl.uniprot.org/uniprot/#_A0A2I3BRX2-mappedCitation-20385772 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20385772 |