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http://purl.uniprot.org/citations/20388015http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20388015http://www.w3.org/2000/01/rdf-schema#comment"

Objective

To determine circulating levels of CD4(+)CD25(high) regulatory T (Treg) cells and transforming growth factor-β (TGF-β) in patients with adult-onset Still's disease (AOSD) and to examine the associations with disease activity and clinical course of this disease.

Methods

The frequencies of circulating CD4(+)CD25(high) Treg cells in 52 active AOSD patients, 42 active systemic lupus erythematosus (SLE) patients, and 22 healthy controls (HCs) were determined using flow cytometry analysis. Levels of serum TGF-β and soluble interleukin-2 receptor (sIL-2R) were measured by enzyme-linked immunosorbent assay.

Results

Significantly lower levels of circulating CD4(+)CD25(high) Treg cells and serum TGF-β were found in AOSD patients and SLE patients than those found in HCs. Levels of circulating CD4(+)CD25(high) Treg cells and TGF-β were inversely correlated with disease activity scores for AOSD patients and SLE patients. Circulating CD4(+)CD25(high) Treg cell frequencies were positively correlated with serum TGF-β levels for patients with both diseases. Levels of circulating CD4(+)CD25(high) Treg cells and TGF-β significantly increased, paralleling clinical remission and the decrease in levels of C-reactive protein and soluble interleukin-2 receptor after effective therapy in AOSD patients. AOSD patients with monocyclic course had significantly higher levels of circulating CD4(+)CD25(high) Treg cells and TGF-β compared to those with polycyclic and chronic articular course.

Conclusion

Diminished levels of circulating CD4(+)CD25(high) Treg cells and TGF-β, and inverse correlation with disease activity in patients with AOSD and SLE might be involved in the pathogenesis of both diseases. Increased levels of circulating CD4(+)CD25(high) Treg cells or TGF-β might be associated with a favorable clinical course in AOSD patients."xsd:string
http://purl.uniprot.org/citations/20388015http://purl.org/dc/terms/identifier"doi:10.3109/03008200903461462"xsd:string
http://purl.uniprot.org/citations/20388015http://purl.uniprot.org/core/author"Chen Y.M."xsd:string
http://purl.uniprot.org/citations/20388015http://purl.uniprot.org/core/author"Lin C.C."xsd:string
http://purl.uniprot.org/citations/20388015http://purl.uniprot.org/core/author"Chen H.H."xsd:string
http://purl.uniprot.org/citations/20388015http://purl.uniprot.org/core/author"Chen D.Y."xsd:string
http://purl.uniprot.org/citations/20388015http://purl.uniprot.org/core/author"Lan J.L."xsd:string
http://purl.uniprot.org/citations/20388015http://purl.uniprot.org/core/author"Hsieh C.W."xsd:string
http://purl.uniprot.org/citations/20388015http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20388015http://purl.uniprot.org/core/name"Connect Tissue Res"xsd:string
http://purl.uniprot.org/citations/20388015http://purl.uniprot.org/core/pages"370-377"xsd:string
http://purl.uniprot.org/citations/20388015http://purl.uniprot.org/core/title"The associations of circulating CD4+CD25high regulatory T cells and TGF-beta with disease activity and clinical course in patients with adult-onset Still's disease."xsd:string
http://purl.uniprot.org/citations/20388015http://purl.uniprot.org/core/volume"51"xsd:string
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