| http://purl.uniprot.org/citations/20388710 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20388710 | http://www.w3.org/2000/01/rdf-schema#comment | "There are four isoforms of the alpha subunit (alpha1-4) and three isoforms of the beta subunit (beta1-3) of Na,K-ATPase, with distinct tissue-specific distribution and physiological functions. alpha2 is thought to play a key role in cardiac and smooth muscle contraction and be an important target of cardiac glycosides. An alpha2-selective cardiac glycoside could provide important insights into physiological and pharmacological properties of alpha2. The isoform selectivity of a large number of cardiac glycosides has been assessed utilizing alpha1beta1, alpha2beta1, and alpha3beta1 isoforms of human Na,K-ATPase expressed in Pichia pastoris and the purified detergent-soluble isoform proteins. Binding affinities of the digitalis glycosides, digoxin, beta-methyl digoxin, and digitoxin show moderate but highly significant selectivity (up to 4-fold) for alpha2/alpha3 over alpha1 (K(D) alpha1 > alpha2 = alpha3). By contrast, ouabain shows moderate selectivity ( approximately 2.5-fold) for alpha1 over alpha2 (K(D) alpha1 xsd:string |
| http://purl.uniprot.org/citations/20388710 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.119248"xsd:string |
| http://purl.uniprot.org/citations/20388710 | http://purl.uniprot.org/core/author | "Katz A."xsd:string |
| http://purl.uniprot.org/citations/20388710 | http://purl.uniprot.org/core/author | "Bab-Dinitz E."xsd:string |
| http://purl.uniprot.org/citations/20388710 | http://purl.uniprot.org/core/author | "Karlish S.J."xsd:string |
| http://purl.uniprot.org/citations/20388710 | http://purl.uniprot.org/core/author | "Goldshleger R."xsd:string |
| http://purl.uniprot.org/citations/20388710 | http://purl.uniprot.org/core/author | "Kapri-Pardes E."xsd:string |
| http://purl.uniprot.org/citations/20388710 | http://purl.uniprot.org/core/author | "Lifshitz Y."xsd:string |
| http://purl.uniprot.org/citations/20388710 | http://purl.uniprot.org/core/author | "Tal D.M."xsd:string |
| http://purl.uniprot.org/citations/20388710 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20388710 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20388710 | http://purl.uniprot.org/core/pages | "19582-19592"xsd:string |
| http://purl.uniprot.org/citations/20388710 | http://purl.uniprot.org/core/title | "Selectivity of digitalis glycosides for isoforms of human Na,K-ATPase."xsd:string |
| http://purl.uniprot.org/citations/20388710 | http://purl.uniprot.org/core/volume | "285"xsd:string |
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