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http://purl.uniprot.org/citations/20392358http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20392358http://www.w3.org/2000/01/rdf-schema#comment"

Setting

Several matrix metalloproteinase (MMP) polymorphisms favouring the development of lung fibrosis after pulmonary tuberculosis (TB) have been described.

Objective

To investigate the association of MMP-1, MMP-9 and MMP-12 polymorphisms with the development of fibrosis in pulmonary TB.

Design

We studied 49 normal subjects and 98 TB patients. We analysed the association between MMP polymorphisms and clinical indices of lung fibrosis by serial chest radiography for 1 year after completion of treatment.

Results

The frequency of the MMP-1(-1607G) polymorphism was significantly higher in TB patients with moderate to advanced pulmonary fibrosis than in those with minimal to mild fibrosis. Having at least one -1607G MMP-1 polymorphism increased the risk of moderate and advanced fibrosis respectively by 5.04 (95%CI 1.25-20.30) and 9.87 (95%CI 2.39-40.88) fold. There was no association of MMP-9(-1562T) and MMP-12(Asn357Ser) polymorphisms with lung fibrosis. The production of MMP-1 from monocytes stimulated by interleukin-1 beta was increased in subjects with the 1G allele genotype compared to the 2G/2G genotype.

Conclusions

Patients with MMP-1(-1607G) polymorphism are more vulnerable to more extensive lung fibrosis 1 year after anti-tuberculosis treatment. This may be related to increased MMP-1 activity, leading to enhanced destruction of the matrix with subsequent fibrosis."xsd:string
http://purl.uniprot.org/citations/20392358http://purl.uniprot.org/core/author"Liu C.Y."xsd:string
http://purl.uniprot.org/citations/20392358http://purl.uniprot.org/core/author"Wang C.H."xsd:string
http://purl.uniprot.org/citations/20392358http://purl.uniprot.org/core/author"Chung K.F."xsd:string
http://purl.uniprot.org/citations/20392358http://purl.uniprot.org/core/author"Lin S.M."xsd:string
http://purl.uniprot.org/citations/20392358http://purl.uniprot.org/core/author"Lin H.C."xsd:string
http://purl.uniprot.org/citations/20392358http://purl.uniprot.org/core/author"Kuo H.P."xsd:string
http://purl.uniprot.org/citations/20392358http://purl.uniprot.org/core/author"Huang K.H."xsd:string
http://purl.uniprot.org/citations/20392358http://purl.uniprot.org/core/author"Hsieh L.L."xsd:string
http://purl.uniprot.org/citations/20392358http://purl.uniprot.org/core/author"Huang C.D."xsd:string
http://purl.uniprot.org/citations/20392358http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20392358http://purl.uniprot.org/core/name"Int J Tuberc Lung Dis"xsd:string
http://purl.uniprot.org/citations/20392358http://purl.uniprot.org/core/pages"627-634"xsd:string
http://purl.uniprot.org/citations/20392358http://purl.uniprot.org/core/title"MMP-1(-1607G) polymorphism as a risk factor for fibrosis after pulmonary tuberculosis in Taiwan."xsd:string
http://purl.uniprot.org/citations/20392358http://purl.uniprot.org/core/volume"14"xsd:string
http://purl.uniprot.org/citations/20392358http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20392358
http://purl.uniprot.org/citations/20392358http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20392358
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http://purl.uniprot.org/uniprot/#_B7Z507-mappedCitation-20392358http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20392358
http://purl.uniprot.org/uniprot/#_B4DN15-mappedCitation-20392358http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20392358
http://purl.uniprot.org/uniprot/#_B4DW26-mappedCitation-20392358http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20392358
http://purl.uniprot.org/uniprot/#_B7Z747-mappedCitation-20392358http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20392358
http://purl.uniprot.org/uniprot/#_B7Z8A9-mappedCitation-20392358http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20392358
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