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http://purl.uniprot.org/citations/20392440http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/20392440http://www.w3.org/2000/01/rdf-schema#comment"Altered neutrophil function may contribute to the development of AIDS during the course of HIV infection. It has been described that Nef, a regulatory protein from HIV, can modulate superoxide production in other cells, therefore altered superoxide production in neutrophils from HIV infected patients, could be secondary to a direct effect of Nef on components of the NADPH oxidase complex. In this work, we describe that Nef, was capable of increasing superoxide production in human neutrophils. Furthermore, a specific association between Nef and p22-phox, a membrane component of the NADPH oxidase complex, was found. We propose that this association may reflect a capability of Nef to modulate by direct association, the enzymatic complex responsible for one of the most efficient innate defense mechanisms in phagocytes, contributing to the pathogenesis of the disease."xsd:string
http://purl.uniprot.org/citations/20392440http://purl.org/dc/terms/identifier"doi:10.1016/j.cellimm.2010.03.012"xsd:string
http://purl.uniprot.org/citations/20392440http://purl.uniprot.org/core/author"Peterson D.L."xsd:string
http://purl.uniprot.org/citations/20392440http://purl.uniprot.org/core/author"Reyes E."xsd:string
http://purl.uniprot.org/citations/20392440http://purl.uniprot.org/core/author"Berrueta L."xsd:string
http://purl.uniprot.org/citations/20392440http://purl.uniprot.org/core/author"Salmen S."xsd:string
http://purl.uniprot.org/citations/20392440http://purl.uniprot.org/core/author"Rosales J.D."xsd:string
http://purl.uniprot.org/citations/20392440http://purl.uniprot.org/core/author"Colmenares M."xsd:string
http://purl.uniprot.org/citations/20392440http://purl.uniprot.org/core/date"2010"xsd:gYear
http://purl.uniprot.org/citations/20392440http://purl.uniprot.org/core/name"Cell Immunol"xsd:string
http://purl.uniprot.org/citations/20392440http://purl.uniprot.org/core/pages"166-171"xsd:string
http://purl.uniprot.org/citations/20392440http://purl.uniprot.org/core/title"HIV-1 Nef associates with p22-phox, a component of the NADPH oxidase protein complex."xsd:string
http://purl.uniprot.org/citations/20392440http://purl.uniprot.org/core/volume"263"xsd:string
http://purl.uniprot.org/citations/20392440http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/20392440
http://purl.uniprot.org/citations/20392440http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/20392440
http://purl.uniprot.org/uniprot/#_B4DT46-mappedCitation-20392440http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20392440
http://purl.uniprot.org/uniprot/#_H3BNP7-mappedCitation-20392440http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20392440
http://purl.uniprot.org/uniprot/#_Q86SL0-mappedCitation-20392440http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20392440
http://purl.uniprot.org/uniprot/#_P13498-mappedCitation-20392440http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20392440
http://purl.uniprot.org/uniprot/#_P04601-mappedCitation-20392440http://www.w3.org/1999/02/22-rdf-syntax-ns#objecthttp://purl.uniprot.org/citations/20392440
http://purl.uniprot.org/uniprot/P04601http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20392440
http://purl.uniprot.org/uniprot/H3BNP7http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20392440
http://purl.uniprot.org/uniprot/B4DT46http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20392440
http://purl.uniprot.org/uniprot/P13498http://purl.uniprot.org/core/mappedCitationhttp://purl.uniprot.org/citations/20392440