| http://purl.uniprot.org/citations/20392746 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20392746 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20392746 | http://www.w3.org/2000/01/rdf-schema#comment | "UNC-51 is a serine/threonine protein kinase conserved from yeast to humans. The yeast homolog Atg1 regulates autophagy (catabolic membrane trafficking) required for surviving starvation. In C. elegans, UNC-51 regulates the axon guidance of many neurons by a different mechanism than it and its homologs use for autophagy. UNC-51 regulates the subcellular localization (trafficking) of UNC-5, a receptor for the axon guidance molecule UNC-6/Netrin; however, the molecular details of the role for UNC-51 are largely unknown. Here, we report that UNC-51 physically interacts with LET-92, the catalytic subunit of serine/threonine protein phosphatase 2A (PP2A-C), which plays important roles in many cellular functions. A low allelic dose of LET-92 partially suppressed axon guidance defects of weak, but not severe, unc-51 mutants, and a low allelic dose of PP2A regulatory subunits A (PAA-1/PP2A-A) and B (SUR-6/PP2A-B) partially enhanced the weak unc-51 mutants. We also found that LET-92 can work cell-non-autonomously on axon guidance in neurons, and that LET-92 colocalized with UNC-51 in neurons. In addition, PP2A dephosphorylated phosphoproteins that had been phosphorylated by UNC-51. These results suggest that, by forming a complex, PP2A cooperates with UNC-51 to regulate axon guidance by regulating phosphorylation. This is the first report of a serine/threonine protein phosphatase functioning in axon guidance in vivo."xsd:string |
| http://purl.uniprot.org/citations/20392746 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.050708"xsd:string |
| http://purl.uniprot.org/citations/20392746 | http://purl.org/dc/terms/identifier | "doi:10.1242/dev.050708"xsd:string |
| http://purl.uniprot.org/citations/20392746 | http://purl.uniprot.org/core/author | "Kohara Y."xsd:string |
| http://purl.uniprot.org/citations/20392746 | http://purl.uniprot.org/core/author | "Kohara Y."xsd:string |
| http://purl.uniprot.org/citations/20392746 | http://purl.uniprot.org/core/author | "Baillie D.L."xsd:string |
| http://purl.uniprot.org/citations/20392746 | http://purl.uniprot.org/core/author | "Baillie D.L."xsd:string |
| http://purl.uniprot.org/citations/20392746 | http://purl.uniprot.org/core/author | "Gengyo-Ando K."xsd:string |
| http://purl.uniprot.org/citations/20392746 | http://purl.uniprot.org/core/author | "Gengyo-Ando K."xsd:string |
| http://purl.uniprot.org/citations/20392746 | http://purl.uniprot.org/core/author | "Goshima Y."xsd:string |
| http://purl.uniprot.org/citations/20392746 | http://purl.uniprot.org/core/author | "Goshima Y."xsd:string |
| http://purl.uniprot.org/citations/20392746 | http://purl.uniprot.org/core/author | "Okada T."xsd:string |
| http://purl.uniprot.org/citations/20392746 | http://purl.uniprot.org/core/author | "Okada T."xsd:string |
| http://purl.uniprot.org/citations/20392746 | http://purl.uniprot.org/core/author | "Mitani S."xsd:string |
| http://purl.uniprot.org/citations/20392746 | http://purl.uniprot.org/core/author | "Mitani S."xsd:string |
| http://purl.uniprot.org/citations/20392746 | http://purl.uniprot.org/core/author | "Ogura K."xsd:string |
| http://purl.uniprot.org/citations/20392746 | http://purl.uniprot.org/core/author | "Ogura K."xsd:string |
| http://purl.uniprot.org/citations/20392746 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20392746 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20392746 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/20392746 | http://purl.uniprot.org/core/name | "Development"xsd:string |
| http://purl.uniprot.org/citations/20392746 | http://purl.uniprot.org/core/pages | "1657-1667"xsd:string |
| http://purl.uniprot.org/citations/20392746 | http://purl.uniprot.org/core/pages | "1657-1667"xsd:string |