| http://purl.uniprot.org/citations/20395209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20395209 | http://www.w3.org/2000/01/rdf-schema#comment | "The branching of complex N-glycans attached to growth factor receptors promotes tumor progression by prolonging growth factor signaling. The addition of the bisecting GlcNAc to complex N-glycans by Mgat3 has varying effects on cell adhesion, cell migration, and hepatoma formation. Here, we show that Chinese hamster ovary cells expressing Mgat3 and the polyoma middle T (PyMT) antigen have reduced cell proliferation and growth factor signaling dependent on a galectin lattice. The Mgat3 gene is not expressed in virgin mammary gland but is upregulated during lactation and is expressed in mouse mammary tumor virus (MMTV)/PyMT tumors. Mice lacking Mgat3 that cannot transfer the bisecting GlcNAc to N-glycans acquire PyMT-induced mammary tumors more rapidly and have an increased tumor burden, increased migration of tumor cells, and increased early metastasis to lung. Tumors and tumor-derived cells lacking Mgat3 exhibit enhanced signaling through the Ras pathway and reduced amounts of functionally glycosylated alpha-dystroglycan. Constitutive overexpression of an MMTV/Mgat3 transgene inhibits early mammary tumor development and tumor cell migration. Thus, the addition of the bisecting GlcNAc to complex N-glycans of mammary tumor cell glycoprotein receptors is a cell autonomous mechanism serving to retard tumor progression by reducing growth factor signaling."xsd:string |
| http://purl.uniprot.org/citations/20395209 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-09-2719"xsd:string |
| http://purl.uniprot.org/citations/20395209 | http://purl.uniprot.org/core/author | "Song Y."xsd:string |
| http://purl.uniprot.org/citations/20395209 | http://purl.uniprot.org/core/author | "Stanley P."xsd:string |
| http://purl.uniprot.org/citations/20395209 | http://purl.uniprot.org/core/author | "Aglipay J.A."xsd:string |
| http://purl.uniprot.org/citations/20395209 | http://purl.uniprot.org/core/author | "Goswami S."xsd:string |
| http://purl.uniprot.org/citations/20395209 | http://purl.uniprot.org/core/author | "Bernstein J.D."xsd:string |
| http://purl.uniprot.org/citations/20395209 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20395209 | http://purl.uniprot.org/core/name | "Cancer Res"xsd:string |
| http://purl.uniprot.org/citations/20395209 | http://purl.uniprot.org/core/pages | "3361-3371"xsd:string |
| http://purl.uniprot.org/citations/20395209 | http://purl.uniprot.org/core/title | "The bisecting GlcNAc on N-glycans inhibits growth factor signaling and retards mammary tumor progression."xsd:string |
| http://purl.uniprot.org/citations/20395209 | http://purl.uniprot.org/core/volume | "70"xsd:string |
| http://purl.uniprot.org/citations/20395209 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20395209 |
| http://purl.uniprot.org/citations/20395209 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20395209 |
| http://purl.uniprot.org/uniprot/#_Q10470-mappedCitation-20395209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20395209 |
| http://purl.uniprot.org/uniprot/#_Q09327-mappedCitation-20395209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20395209 |
| http://purl.uniprot.org/uniprot/#_Q5RKT9-mappedCitation-20395209 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20395209 |
| http://purl.uniprot.org/uniprot/Q09327 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20395209 |
| http://purl.uniprot.org/uniprot/Q5RKT9 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20395209 |
| http://purl.uniprot.org/uniprot/Q10470 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/20395209 |