| http://purl.uniprot.org/citations/20395633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20395633 | http://www.w3.org/2000/01/rdf-schema#comment | "Sialic acid-binding immunoglobulin-like lectin (Siglec)-F, an inhibitory receptor on mouse eosinophils, preferentially recognizes the glycan ligand 6'-sulfated sialyl Lewis X, but little is known about the requirements for its lung expression. RT-PCR and immunohistochemistry were used to detect and localize the sulfotransferase keratin sulfate galactose 6-O sulfotransferase (KSGal6ST, also known as carbohydrate sulfotransferase 1; gene name, Chst1) that is putatively required for 6'-sulfated Sialyl Lewis X synthesis. RT-PCR detected the greatest constitutive expression of Chst1 in lung, liver, and spleen tissue. Immunohistochemistry localized the expression of KSGal6ST in lung tissue primarily to airway epithelium. Siglec-F-Ig fusion protein selectively bound in a similar pattern, and was unaffected in lung tissue treated with methanol or deficient in Type 2 α2,3 sialyltransferase (St3gal2), but was eliminated by proteinase K or sialidase, and was absent in tissue deficient in the Type 3 α2,3 sialyltransferase (St3gal3). Binding of the Siglec-F-Ig fusion protein was similar in pattern to, and completely blocked by, a plant lectin recognizing α2,3-linked sialic acid. Thus, α2,3-linked sialic acid-containing glycoprotein Siglec-F ligands and the enzymes required for their synthesis are constitutively expressed in murine lungs, especially by airway epithelium. St3gal3, but not St3gal2, is required for constitutive Siglec-F ligand synthesis. The survival of eosinophils entering the lung may be shortened by encountering these Siglec-F sialoside ligands."xsd:string |
| http://purl.uniprot.org/citations/20395633 | http://purl.org/dc/terms/identifier | "doi:10.1165/rcmb.2010-0007oc"xsd:string |
| http://purl.uniprot.org/citations/20395633 | http://purl.uniprot.org/core/author | "Rowland E."xsd:string |
| http://purl.uniprot.org/citations/20395633 | http://purl.uniprot.org/core/author | "Zheng T."xsd:string |
| http://purl.uniprot.org/citations/20395633 | http://purl.uniprot.org/core/author | "Zhu Z."xsd:string |
| http://purl.uniprot.org/citations/20395633 | http://purl.uniprot.org/core/author | "Schnaar R.L."xsd:string |
| http://purl.uniprot.org/citations/20395633 | http://purl.uniprot.org/core/author | "Myers A.C."xsd:string |
| http://purl.uniprot.org/citations/20395633 | http://purl.uniprot.org/core/author | "Guo J.P."xsd:string |
| http://purl.uniprot.org/citations/20395633 | http://purl.uniprot.org/core/author | "Bochner B.S."xsd:string |
| http://purl.uniprot.org/citations/20395633 | http://purl.uniprot.org/core/author | "Na H.J."xsd:string |
| http://purl.uniprot.org/citations/20395633 | http://purl.uniprot.org/core/author | "Brummet M.E."xsd:string |
| http://purl.uniprot.org/citations/20395633 | http://purl.uniprot.org/core/date | "2011"xsd:gYear |
| http://purl.uniprot.org/citations/20395633 | http://purl.uniprot.org/core/name | "Am J Respir Cell Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/20395633 | http://purl.uniprot.org/core/pages | "238-243"xsd:string |
| http://purl.uniprot.org/citations/20395633 | http://purl.uniprot.org/core/title | "Characterization of expression of glycan ligands for Siglec-F in normal mouse lungs."xsd:string |
| http://purl.uniprot.org/citations/20395633 | http://purl.uniprot.org/core/volume | "44"xsd:string |
| http://purl.uniprot.org/citations/20395633 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20395633 |
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