| http://purl.uniprot.org/citations/20398058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20398058 | http://www.w3.org/2000/01/rdf-schema#comment | "Y-box binding protein-1 (YB-1) is a member of the cold shock protein family and functions in transcription and translation. Many reports indicate that YB-1 is highly expressed in tumor cells and is a marker for tumor aggressiveness and clinical prognosis. Here, we show clear evidence that YB-1 is expressed in the angiogenic endothelial cells of various tumors, such as glioblastoma, esophageal cancer, gastric cancer, colon cancer, and lung cancer, as well as in tumor cells. YB-1 was highly expressed in glomeruloid microvascular endothelial cells of brain tumors and microvessels in the desmoplastic region around multiple solid tumors. On the other hand, no or low YB-1 expression was observed in normal angiogenic endothelial cells from fetal kidney, newborn lung, and placenta. The endothelial cells in inflammatory regions of granulomas were also weakly labeled. Knockdown of YB-1 expression by small-interfering RNA induced G1 cell cycle arrest and inhibited the growth of human umbilical vein endothelial cells stimulated by growth factors. Taken together, YB-1 plays an important role in the growth of not only tumor cells but also tumor-associated endothelial cells, suggesting that YB-1 is a promising target for cancer therapy."xsd:string |
| http://purl.uniprot.org/citations/20398058 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1349-7006.2010.01534.x"xsd:string |
| http://purl.uniprot.org/citations/20398058 | http://purl.uniprot.org/core/author | "Han B."xsd:string |
| http://purl.uniprot.org/citations/20398058 | http://purl.uniprot.org/core/author | "Kohno K."xsd:string |
| http://purl.uniprot.org/citations/20398058 | http://purl.uniprot.org/core/author | "Takahashi M."xsd:string |
| http://purl.uniprot.org/citations/20398058 | http://purl.uniprot.org/core/author | "Wu Y."xsd:string |
| http://purl.uniprot.org/citations/20398058 | http://purl.uniprot.org/core/author | "Akiyama M."xsd:string |
| http://purl.uniprot.org/citations/20398058 | http://purl.uniprot.org/core/author | "Sasaguri Y."xsd:string |
| http://purl.uniprot.org/citations/20398058 | http://purl.uniprot.org/core/author | "Izumi H."xsd:string |
| http://purl.uniprot.org/citations/20398058 | http://purl.uniprot.org/core/author | "Nishizawa S."xsd:string |
| http://purl.uniprot.org/citations/20398058 | http://purl.uniprot.org/core/author | "Shimajiri S."xsd:string |
| http://purl.uniprot.org/citations/20398058 | http://purl.uniprot.org/core/author | "Kashiwagi E."xsd:string |
| http://purl.uniprot.org/citations/20398058 | http://purl.uniprot.org/core/author | "Hirano G."xsd:string |
| http://purl.uniprot.org/citations/20398058 | http://purl.uniprot.org/core/author | "Yasuniwa Y."xsd:string |
| http://purl.uniprot.org/citations/20398058 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20398058 | http://purl.uniprot.org/core/name | "Cancer Sci"xsd:string |
| http://purl.uniprot.org/citations/20398058 | http://purl.uniprot.org/core/pages | "1367-1373"xsd:string |
| http://purl.uniprot.org/citations/20398058 | http://purl.uniprot.org/core/title | "Y-box binding protein-1 is a novel molecular target for tumor vessels."xsd:string |
| http://purl.uniprot.org/citations/20398058 | http://purl.uniprot.org/core/volume | "101"xsd:string |
| http://purl.uniprot.org/citations/20398058 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20398058 |
| http://purl.uniprot.org/citations/20398058 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20398058 |
| http://purl.uniprot.org/uniprot/#_A0JLU4-mappedCitation-20398058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20398058 |
| http://purl.uniprot.org/uniprot/#_Q6PKI6-mappedCitation-20398058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20398058 |
| http://purl.uniprot.org/uniprot/#_P67809-mappedCitation-20398058 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20398058 |