| http://purl.uniprot.org/citations/20399731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20399731 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20399731 | http://www.w3.org/2000/01/rdf-schema#comment | "The hair-cell tip link, a fine filament directly conveying force to mechanosensitive transduction channels, is composed of two proteins, protocadherin-15 and cadherin-23, whose mutation causes deafness. However, their molecular structure, elasticity, and deafness-related structural defects are unknown. We present crystal structures of the first and second extracellular cadherin repeats of cadherin-23. Overall, structures show typical cadherin folds, but reveal an elongated N terminus that precludes classical cadherin interactions and contributes to an N-terminal Ca(2+)-binding site. The deafness mutation D101G, in the linker region between the repeats, causes a slight bend between repeats and decreases Ca(2+) affinity. Molecular dynamics simulations suggest that cadherin-23 repeats are stiff and that either removing Ca(2+) or mutating Ca(2+)-binding residues reduces rigidity and unfolding strength. The structures define an uncharacterized cadherin family and, with simulations, suggest mechanisms underlying inherited deafness and how cadherin-23 may bind with itself and with protocadherin-15 to form the tip link."xsd:string |
| http://purl.uniprot.org/citations/20399731 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2010.03.028"xsd:string |
| http://purl.uniprot.org/citations/20399731 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.neuron.2010.03.028"xsd:string |
| http://purl.uniprot.org/citations/20399731 | http://purl.uniprot.org/core/author | "Gaudet R."xsd:string |
| http://purl.uniprot.org/citations/20399731 | http://purl.uniprot.org/core/author | "Gaudet R."xsd:string |
| http://purl.uniprot.org/citations/20399731 | http://purl.uniprot.org/core/author | "Weihofen W.A."xsd:string |
| http://purl.uniprot.org/citations/20399731 | http://purl.uniprot.org/core/author | "Weihofen W.A."xsd:string |
| http://purl.uniprot.org/citations/20399731 | http://purl.uniprot.org/core/author | "Sotomayor M."xsd:string |
| http://purl.uniprot.org/citations/20399731 | http://purl.uniprot.org/core/author | "Sotomayor M."xsd:string |
| http://purl.uniprot.org/citations/20399731 | http://purl.uniprot.org/core/author | "Corey D.P."xsd:string |
| http://purl.uniprot.org/citations/20399731 | http://purl.uniprot.org/core/author | "Corey D.P."xsd:string |
| http://purl.uniprot.org/citations/20399731 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20399731 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20399731 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/20399731 | http://purl.uniprot.org/core/name | "Neuron"xsd:string |
| http://purl.uniprot.org/citations/20399731 | http://purl.uniprot.org/core/pages | "85-100"xsd:string |
| http://purl.uniprot.org/citations/20399731 | http://purl.uniprot.org/core/pages | "85-100"xsd:string |
| http://purl.uniprot.org/citations/20399731 | http://purl.uniprot.org/core/title | "Structural determinants of cadherin-23 function in hearing and deafness."xsd:string |
| http://purl.uniprot.org/citations/20399731 | http://purl.uniprot.org/core/title | "Structural determinants of cadherin-23 function in hearing and deafness."xsd:string |
| http://purl.uniprot.org/citations/20399731 | http://purl.uniprot.org/core/volume | "66"xsd:string |
| http://purl.uniprot.org/citations/20399731 | http://purl.uniprot.org/core/volume | "66"xsd:string |
| http://purl.uniprot.org/citations/20399731 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20399731 |
| http://purl.uniprot.org/citations/20399731 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20399731 |