| http://purl.uniprot.org/citations/20400509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20400509 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20400509 | http://www.w3.org/2000/01/rdf-schema#comment | "Signal transduction by Toll-like receptor 2 (TLR2) and TLR4 requires the adaptors MyD88 and Mal (MyD88 adaptor-like) and serine/threonine kinases, interleukin-1 receptor-associated kinases IRAK1 and IRAK4. We have found that both IRAK1 and IRAK4 can directly phosphorylate Mal. In addition, co-expression of Mal with either IRAK resulted in depletion of Mal from cell lysates. This is likely to be due to Mal phosphorylation by the IRAKs because kinase-inactive forms of either IRAK had no effect. Furthermore, lipopolysaccharide stimulation resulted in ubiquitination and degradation of Mal, which was inhibited using an IRAK1/4 inhibitor or by knocking down expression of IRAK1 and IRAK4. MyD88 is not a substrate for either IRAK and did not undergo degradation. We therefore conclude that Mal is a substrate for IRAK1 and IRAK4 with phosphorylation promoting ubiquitination and degradation of Mal. This process may serve to negatively regulate signaling by TLR2 and TLR4."xsd:string |
| http://purl.uniprot.org/citations/20400509 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.098137"xsd:string |
| http://purl.uniprot.org/citations/20400509 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m109.098137"xsd:string |
| http://purl.uniprot.org/citations/20400509 | http://purl.uniprot.org/core/author | "Gray P."xsd:string |
| http://purl.uniprot.org/citations/20400509 | http://purl.uniprot.org/core/author | "Gray P."xsd:string |
| http://purl.uniprot.org/citations/20400509 | http://purl.uniprot.org/core/author | "Morrice N."xsd:string |
| http://purl.uniprot.org/citations/20400509 | http://purl.uniprot.org/core/author | "Morrice N."xsd:string |
| http://purl.uniprot.org/citations/20400509 | http://purl.uniprot.org/core/author | "O'Neill L.A."xsd:string |
| http://purl.uniprot.org/citations/20400509 | http://purl.uniprot.org/core/author | "O'Neill L.A."xsd:string |
| http://purl.uniprot.org/citations/20400509 | http://purl.uniprot.org/core/author | "Carpenter S."xsd:string |
| http://purl.uniprot.org/citations/20400509 | http://purl.uniprot.org/core/author | "Carpenter S."xsd:string |
| http://purl.uniprot.org/citations/20400509 | http://purl.uniprot.org/core/author | "Strelow A."xsd:string |
| http://purl.uniprot.org/citations/20400509 | http://purl.uniprot.org/core/author | "Strelow A."xsd:string |
| http://purl.uniprot.org/citations/20400509 | http://purl.uniprot.org/core/author | "Wesche H."xsd:string |
| http://purl.uniprot.org/citations/20400509 | http://purl.uniprot.org/core/author | "Wesche H."xsd:string |
| http://purl.uniprot.org/citations/20400509 | http://purl.uniprot.org/core/author | "Brikos C."xsd:string |
| http://purl.uniprot.org/citations/20400509 | http://purl.uniprot.org/core/author | "Brikos C."xsd:string |
| http://purl.uniprot.org/citations/20400509 | http://purl.uniprot.org/core/author | "Dunne A."xsd:string |
| http://purl.uniprot.org/citations/20400509 | http://purl.uniprot.org/core/author | "Dunne A."xsd:string |
| http://purl.uniprot.org/citations/20400509 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20400509 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20400509 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/20400509 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |