| http://purl.uniprot.org/citations/20400699 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20400699 | http://www.w3.org/2000/01/rdf-schema#comment | "Tuning of TCR-mediated activation was demonstrated to be critical for lineage fate in T cell development, as well as in the control of autoimmunity. In this study, we identify a novel diabetes susceptibility gene, Idd28, in the NOD mouse and provide evidence that Cd3zeta (Cd247) constitutes a prime candidate gene for this locus. Moreover, we show that the allele of the Cd3zeta gene expressed in NOD and DBA/2 mouse strains confers lower levels of T cell activation compared with the allele expressed by C57BL/6 (B6), BALB/c, and C3H/HeJ mice. These results support a model in which the development of autoimmune diabetes is dependent on a TCR signal mediated by a less-efficient NOD allele of the Cd3zeta gene."xsd:string |
| http://purl.uniprot.org/citations/20400699 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.0904012"xsd:string |
| http://purl.uniprot.org/citations/20400699 | http://purl.uniprot.org/core/author | "Motta V."xsd:string |
| http://purl.uniprot.org/citations/20400699 | http://purl.uniprot.org/core/author | "Holmberg D."xsd:string |
| http://purl.uniprot.org/citations/20400699 | http://purl.uniprot.org/core/author | "Lundholm M."xsd:string |
| http://purl.uniprot.org/citations/20400699 | http://purl.uniprot.org/core/author | "Lofgren-Burstrom A."xsd:string |
| http://purl.uniprot.org/citations/20400699 | http://purl.uniprot.org/core/author | "Danska J."xsd:string |
| http://purl.uniprot.org/citations/20400699 | http://purl.uniprot.org/core/author | "Mayans S."xsd:string |
| http://purl.uniprot.org/citations/20400699 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20400699 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/20400699 | http://purl.uniprot.org/core/pages | "5537-5544"xsd:string |
| http://purl.uniprot.org/citations/20400699 | http://purl.uniprot.org/core/title | "Variation in the Cd3 zeta (Cd247) gene correlates with altered T cell activation and is associated with autoimmune diabetes."xsd:string |
| http://purl.uniprot.org/citations/20400699 | http://purl.uniprot.org/core/volume | "184"xsd:string |
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