| http://purl.uniprot.org/citations/20400939 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20400939 | http://www.w3.org/2000/01/rdf-schema#comment | "MicroRNAs (miRNAs) have been implicated in cell-cycle regulation and in some cases shown to have a role in tissue growth control. Depletion of miRNAs was found to have an effect on tissue growth rates in the wing primordium of Drosophila, a highly proliferative epithelium. Dicer-1 (Dcr-1) is a double-stranded RNAseIII essential for miRNA biogenesis. Adult cells lacking dcr-1, or with reduced dcr-1 activity, were smaller than normal cells and gave rise to smaller wings. dcr-1 mutant cells showed evidence of being susceptible to competition by faster growing cells in vivo and the miRNA machinery was shown to promote G(1)-S transition. We present evidence that Dcr-1 acts by regulating the TRIM-NHL protein Mei-P26, which in turn regulates dMyc protein levels. Mei-P26 is a direct target of miRNAs, including the growth-promoting bantam miRNA. Thus, regulation of tissue growth by the miRNA pathway involves a double repression mechanism to control dMyc protein levels in a highly proliferative and growing epithelium."xsd:string |
| http://purl.uniprot.org/citations/20400939 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2010.69"xsd:string |
| http://purl.uniprot.org/citations/20400939 | http://purl.uniprot.org/core/author | "Cohen S.M."xsd:string |
| http://purl.uniprot.org/citations/20400939 | http://purl.uniprot.org/core/author | "Ferreira A."xsd:string |
| http://purl.uniprot.org/citations/20400939 | http://purl.uniprot.org/core/author | "Perez L."xsd:string |
| http://purl.uniprot.org/citations/20400939 | http://purl.uniprot.org/core/author | "Hong X."xsd:string |
| http://purl.uniprot.org/citations/20400939 | http://purl.uniprot.org/core/author | "Olivieri D."xsd:string |
| http://purl.uniprot.org/citations/20400939 | http://purl.uniprot.org/core/author | "Milan M."xsd:string |
| http://purl.uniprot.org/citations/20400939 | http://purl.uniprot.org/core/author | "Herranz H."xsd:string |
| http://purl.uniprot.org/citations/20400939 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20400939 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/20400939 | http://purl.uniprot.org/core/pages | "1688-1698"xsd:string |
| http://purl.uniprot.org/citations/20400939 | http://purl.uniprot.org/core/title | "The miRNA machinery targets Mei-P26 and regulates Myc protein levels in the Drosophila wing."xsd:string |
| http://purl.uniprot.org/citations/20400939 | http://purl.uniprot.org/core/volume | "29"xsd:string |
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