| http://purl.uniprot.org/citations/20400952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20400952 | http://www.w3.org/2000/01/rdf-schema#comment | "One key question in protein biosynthesis is how the ribosome couples mRNA and tRNA movements to prevent disruption of weak codon-anticodon interactions and loss of the translational reading frame during translocation. Here we report the complete path of mRNA on the 70S ribosome at the atomic level (3.1-A resolution), and we show that one of the conformational rearrangements that occurs upon transition from initiation to elongation is a narrowing of the downstream mRNA tunnel. This rearrangement triggers formation of a network of interactions between the mRNA downstream of the A-site codon and the elongating ribosome. Our data elucidate the mechanism by which hypermodified nucleoside 2-methylthio-N6 isopentenyl adenosine at position 37 (ms(2)i(6)A37) in tRNA(Phe)(GAA) stabilizes mRNA-tRNA interactions in all three tRNA binding sites. Another network of contacts is formed between this tRNA modification and ribosomal elements surrounding the mRNA E/P kink, resulting in the anchoring of P-site tRNA. These data allow rationalization of how modification deficiencies of ms(2)i(6)A37 in tRNAs may lead to shifts of the translational reading frame."xsd:string |
| http://purl.uniprot.org/citations/20400952 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb.1790"xsd:string |
| http://purl.uniprot.org/citations/20400952 | http://purl.uniprot.org/core/author | "Yusupov M."xsd:string |
| http://purl.uniprot.org/citations/20400952 | http://purl.uniprot.org/core/author | "Yusupova G."xsd:string |
| http://purl.uniprot.org/citations/20400952 | http://purl.uniprot.org/core/author | "Jenner L.B."xsd:string |
| http://purl.uniprot.org/citations/20400952 | http://purl.uniprot.org/core/author | "Demeshkina N."xsd:string |
| http://purl.uniprot.org/citations/20400952 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20400952 | http://purl.uniprot.org/core/name | "Nat Struct Mol Biol"xsd:string |
| http://purl.uniprot.org/citations/20400952 | http://purl.uniprot.org/core/pages | "555-560"xsd:string |
| http://purl.uniprot.org/citations/20400952 | http://purl.uniprot.org/core/title | "Structural aspects of messenger RNA reading frame maintenance by the ribosome."xsd:string |
| http://purl.uniprot.org/citations/20400952 | http://purl.uniprot.org/core/volume | "17"xsd:string |
| http://purl.uniprot.org/citations/20400952 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20400952 |
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| http://purl.uniprot.org/uniprot/#_P0DOY7-mappedCitation-20400952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20400952 |
| http://purl.uniprot.org/uniprot/#_P0DOY8-mappedCitation-20400952 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20400952 |
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