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| http://purl.uniprot.org/citations/20404916 | http://www.w3.org/2000/01/rdf-schema#comment | "The Mal/SRF transcription factor is regulated by the level of G-actin in cells and has important roles in cell migration and other actin-dependent processes in Drosophila. A recent report suggests that Mal/SRF and an upstream regulator, Pico, are required for cell proliferation and tissue growth in Drosophila. I find otherwise. Mutation of Mal or SRF does not affect cell proliferation in the fly wing. Furthermore, I cannot reproduce the reported effects of Pico RNAi or Pico overexpression on body size. Nevertheless, I can confirm that overexpression of Pico or Mal causes tissue overgrowth specifically in the fly wing--where SRF is most highly expressed. My results indicate that Mal/SRF can promote tissue growth when abnormally active, but is not normally required for tissue growth during development."xsd:string |
| http://purl.uniprot.org/citations/20404916 | http://purl.org/dc/terms/identifier | "doi:10.1371/journal.pone.0010077"xsd:string |
| http://purl.uniprot.org/citations/20404916 | http://purl.uniprot.org/core/author | "Thompson B.J."xsd:string |
| http://purl.uniprot.org/citations/20404916 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20404916 | http://purl.uniprot.org/core/name | "PLoS One"xsd:string |
| http://purl.uniprot.org/citations/20404916 | http://purl.uniprot.org/core/pages | "e10077"xsd:string |
| http://purl.uniprot.org/citations/20404916 | http://purl.uniprot.org/core/title | "Mal/SRF is dispensable for cell proliferation in Drosophila."xsd:string |
| http://purl.uniprot.org/citations/20404916 | http://purl.uniprot.org/core/volume | "5"xsd:string |
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