| http://purl.uniprot.org/citations/20406889 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20406889 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the bone morphogenetic protein (BMP) family have been implicated in the development and maintenance of vascular systems. Whereas members of the BMP-2/4 and osteogenic protein-1 groups signal via activin receptor-like kinase (ALK)-2, ALK-3 and ALK-6, BMP-9 and BMP-10 have been reported to bind to ALK-1 in endothelial cells. However, the roles of BMP-9-ALK-1 signaling in the regulation of endothelial cells have not yet been fully elucidated. Here, using various systems, we examined the effects of BMP-9 on the proliferation of endothelial cells. Vascular-tube formation from ex vivo allantoic explants of mouse embryos was promoted by BMP-9. BMP-9, as well as BMP-4 and BMP-6, also induced the proliferation of in-vitro-cultured mouse embryonic-stem-cell-derived endothelial cells (MESECs) by inducing the expression of vascular endothelial growth factor receptor 2 and Tie2, a receptor for angiopoietin-1. A decrease in ALK-1 expression or expression of constitutively active ALK-1 in MESECs abrogated and mimicked the effects of BMP-9 on the proliferation of MESECs, respectively, suggesting that BMP-9 promotes the proliferation of these cells via ALK-1. Furthermore, in vivo angiogenesis was promoted by BMP-9 in a Matrigel plug assay and in a BxPC3 xenograft model of human pancreatic cancer. Consistent with these in vivo findings, BMP-9 enhanced the proliferation of in-vitro-cultured normal endothelial cells from dermal tissues of adult mice and of tumor-associated endothelial cells isolated from tumor xenografts in host mice. These findings suggest that BMP-9 signaling activates the endothelium tested in the present study via ALK-1."xsd:string |
| http://purl.uniprot.org/citations/20406889 | http://purl.org/dc/terms/identifier | "doi:10.1242/jcs.061556"xsd:string |
| http://purl.uniprot.org/citations/20406889 | http://purl.uniprot.org/core/author | "Suzuki Y."xsd:string |
| http://purl.uniprot.org/citations/20406889 | http://purl.uniprot.org/core/author | "Morishita Y."xsd:string |
| http://purl.uniprot.org/citations/20406889 | http://purl.uniprot.org/core/author | "Miyazono K."xsd:string |
| http://purl.uniprot.org/citations/20406889 | http://purl.uniprot.org/core/author | "Watabe T."xsd:string |
| http://purl.uniprot.org/citations/20406889 | http://purl.uniprot.org/core/author | "Hida K."xsd:string |
| http://purl.uniprot.org/citations/20406889 | http://purl.uniprot.org/core/author | "Ohga N."xsd:string |
| http://purl.uniprot.org/citations/20406889 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20406889 | http://purl.uniprot.org/core/name | "J Cell Sci"xsd:string |
| http://purl.uniprot.org/citations/20406889 | http://purl.uniprot.org/core/pages | "1684-1692"xsd:string |
| http://purl.uniprot.org/citations/20406889 | http://purl.uniprot.org/core/title | "BMP-9 induces proliferation of multiple types of endothelial cells in vitro and in vivo."xsd:string |
| http://purl.uniprot.org/citations/20406889 | http://purl.uniprot.org/core/volume | "123"xsd:string |
| http://purl.uniprot.org/citations/20406889 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20406889 |
| http://purl.uniprot.org/citations/20406889 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20406889 |
| http://purl.uniprot.org/uniprot/P37023#attribution-FE6B179856EF82F8240D948900CF6AFC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20406889 |
| http://purl.uniprot.org/uniprot/Q61288#attribution-7511F9ECAE22D5E8A74BF3C37DEE1712 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20406889 |
| http://purl.uniprot.org/uniprot/Q61288#attribution-9E4DF3003BF24DE2D3E17D010F388F22 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20406889 |
| http://purl.uniprot.org/uniprot/Q61288#attribution-FE6B179856EF82F8240D948900CF6AFC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20406889 |
| http://purl.uniprot.org/uniprot/O08538#attribution-FE6B179856EF82F8240D948900CF6AFC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20406889 |
| http://purl.uniprot.org/uniprot/P21275#attribution-7511F9ECAE22D5E8A74BF3C37DEE1712 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20406889 |
| http://purl.uniprot.org/uniprot/P21275#attribution-FE6B179856EF82F8240D948900CF6AFC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20406889 |
| http://purl.uniprot.org/uniprot/P20722#attribution-7511F9ECAE22D5E8A74BF3C37DEE1712 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20406889 |
| http://purl.uniprot.org/uniprot/Q9WV56#attribution-7511F9ECAE22D5E8A74BF3C37DEE1712 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/20406889 |