| http://purl.uniprot.org/citations/20407419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20407419 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20407419 | http://www.w3.org/2000/01/rdf-schema#comment | "Amassments of heterochromatin in somatic cells occur in close contact with the nuclear envelope (NE) but are gapped by channel- and cone-like zones that appear largely free of heterochromatin and associated with the nuclear pore complexes (NPCs). To identify proteins involved in forming such heterochromatin exclusion zones (HEZs), we used a cell culture model in which chromatin condensation induced by poliovirus (PV) infection revealed HEZs resembling those in normal tissue cells. HEZ occurrence depended on the NPC-associated protein Tpr and its large coiled coil-forming domain. RNAi-mediated loss of Tpr allowed condensing chromatin to occur all along the NE's nuclear surface, resulting in HEZs no longer being established and NPCs covered by heterochromatin. These results assign a central function to Tpr as a determinant of perinuclear organization, with a direct role in forming a morphologically distinct nuclear sub-compartment and delimiting heterochromatin distribution."xsd:string |
| http://purl.uniprot.org/citations/20407419 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2010.54"xsd:string |
| http://purl.uniprot.org/citations/20407419 | http://purl.org/dc/terms/identifier | "doi:10.1038/emboj.2010.54"xsd:string |
| http://purl.uniprot.org/citations/20407419 | http://purl.uniprot.org/core/author | "Norder H."xsd:string |
| http://purl.uniprot.org/citations/20407419 | http://purl.uniprot.org/core/author | "Norder H."xsd:string |
| http://purl.uniprot.org/citations/20407419 | http://purl.uniprot.org/core/author | "Thyberg J."xsd:string |
| http://purl.uniprot.org/citations/20407419 | http://purl.uniprot.org/core/author | "Thyberg J."xsd:string |
| http://purl.uniprot.org/citations/20407419 | http://purl.uniprot.org/core/author | "Cordes V.C."xsd:string |
| http://purl.uniprot.org/citations/20407419 | http://purl.uniprot.org/core/author | "Cordes V.C."xsd:string |
| http://purl.uniprot.org/citations/20407419 | http://purl.uniprot.org/core/author | "Boysen B."xsd:string |
| http://purl.uniprot.org/citations/20407419 | http://purl.uniprot.org/core/author | "Boysen B."xsd:string |
| http://purl.uniprot.org/citations/20407419 | http://purl.uniprot.org/core/author | "Dorries J."xsd:string |
| http://purl.uniprot.org/citations/20407419 | http://purl.uniprot.org/core/author | "Dorries J."xsd:string |
| http://purl.uniprot.org/citations/20407419 | http://purl.uniprot.org/core/author | "Krull S."xsd:string |
| http://purl.uniprot.org/citations/20407419 | http://purl.uniprot.org/core/author | "Krull S."xsd:string |
| http://purl.uniprot.org/citations/20407419 | http://purl.uniprot.org/core/author | "Magnius L."xsd:string |
| http://purl.uniprot.org/citations/20407419 | http://purl.uniprot.org/core/author | "Magnius L."xsd:string |
| http://purl.uniprot.org/citations/20407419 | http://purl.uniprot.org/core/author | "Reidenbach S."xsd:string |
| http://purl.uniprot.org/citations/20407419 | http://purl.uniprot.org/core/author | "Reidenbach S."xsd:string |
| http://purl.uniprot.org/citations/20407419 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20407419 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20407419 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/20407419 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |