| http://purl.uniprot.org/citations/20408569 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20408569 | http://www.w3.org/2000/01/rdf-schema#comment | "Dictyostelium discoideum amoebae were exposed to Hg 2 microM corresponding to a sublethal concentration and Hg 10 microM with the first effects on mortality and replication rate. A total of 900 spots were visualized by 2-DE electrophoresis. Two-hundred fifty single proteins were identified by mass spectrometry. Low Hg concentration (2 microM) treatment induced up-regulation of 13 spots, mainly involved in oxidative stress response/detoxification, oxidoreductase activity, and metabolic processes. High Hg concentration (10 microM) treatment showed a different PES with 12 proteins downregulated and only two up-regulated, mainly involved in cellular metabolic processes, metal ion binding, and transferase activity. The analyses for the carbonylation show no changes after 2 microM Hg(2+) treatment and 13 differentially carbonylated proteins after 10 microM Hg(2+) involved in a broad range of cellular processes. Our findings provide insight into the mechanisms of physiological adaptation and toxicity to a low and an high mercury concentration, respectively, of Dictyostelium amoebae."xsd:string |
| http://purl.uniprot.org/citations/20408569 | http://purl.org/dc/terms/identifier | "doi:10.1021/pr900914t"xsd:string |
| http://purl.uniprot.org/citations/20408569 | http://purl.uniprot.org/core/author | "Cavaletto M."xsd:string |
| http://purl.uniprot.org/citations/20408569 | http://purl.uniprot.org/core/author | "Dondero F."xsd:string |
| http://purl.uniprot.org/citations/20408569 | http://purl.uniprot.org/core/author | "Viarengo A."xsd:string |
| http://purl.uniprot.org/citations/20408569 | http://purl.uniprot.org/core/author | "Magnelli V."xsd:string |
| http://purl.uniprot.org/citations/20408569 | http://purl.uniprot.org/core/author | "Marsano F."xsd:string |
| http://purl.uniprot.org/citations/20408569 | http://purl.uniprot.org/core/author | "Ranzato E."xsd:string |
| http://purl.uniprot.org/citations/20408569 | http://purl.uniprot.org/core/author | "Boatti L."xsd:string |
| http://purl.uniprot.org/citations/20408569 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20408569 | http://purl.uniprot.org/core/name | "J Proteome Res"xsd:string |
| http://purl.uniprot.org/citations/20408569 | http://purl.uniprot.org/core/pages | "2839-2854"xsd:string |
| http://purl.uniprot.org/citations/20408569 | http://purl.uniprot.org/core/title | "Effects of mercury on Dictyostelium discoideum: proteomics reveals the molecular mechanisms of physiological adaptation and toxicity."xsd:string |
| http://purl.uniprot.org/citations/20408569 | http://purl.uniprot.org/core/volume | "9"xsd:string |
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