| http://purl.uniprot.org/citations/20410302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20410302 | http://www.w3.org/2000/01/rdf-schema#comment | "The mammalian target of rapamycin (mTOR) and S6 kinase (S6K) pathway is essential for cell differentiation, growth, and survival. Phospholipase D2 (PLD2) plays a key role in mTOR/S6K mitogenic signaling. However, the impact of PLD on mTOR/S6K gene expression is not known. Here we show that interleukin-8 (IL-8) increases mRNA expression levels for PLD2, mTOR, and S6K, with PLD2 preceding mTOR/S6K in time. Silencing of PLD2 gene expression abrogated IL-8-induced mTOR/S6K mRNA expression, whereas silencing of mTOR or S6K gene expression resulted in large (>3-fold and >5-fold, respectively) increased levels of PLD2 RNA, which was paralleled by increases in protein expression and lipase activity. Treatment of cells with 0.5 nm rapamycin induced a similar trend. These results suggest that, under basal conditions, PLD2 expression and concomitant activity is negatively regulated by the mTOR/S6K signaling pathway. Down-regulation of PLD2 was confirmed in differentiated HL-60 leukocytes overexpressing an mTOR-wild type, but not an mTOR kinase-dead construct. At the cellular level, overexpression of mTOR-wild type resulted in lower basal cell migration, which was reversed by treatment with IL-8. We propose that IL-8 reverses an mTOR/S6K-led down-regulation of PLD2 expression and enables PLD2 to fully function as a facilitator for cell migration."xsd:string |
| http://purl.uniprot.org/citations/20410302 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m110.111542"xsd:string |
| http://purl.uniprot.org/citations/20410302 | http://purl.uniprot.org/core/author | "Dougherty K."xsd:string |
| http://purl.uniprot.org/citations/20410302 | http://purl.uniprot.org/core/author | "Di Fulvio M."xsd:string |
| http://purl.uniprot.org/citations/20410302 | http://purl.uniprot.org/core/author | "Gomez-Cambronero J."xsd:string |
| http://purl.uniprot.org/citations/20410302 | http://purl.uniprot.org/core/author | "Tabatabaian F."xsd:string |
| http://purl.uniprot.org/citations/20410302 | http://purl.uniprot.org/core/date | "2010"xsd:gYear |
| http://purl.uniprot.org/citations/20410302 | http://purl.uniprot.org/core/name | "J Biol Chem"xsd:string |
| http://purl.uniprot.org/citations/20410302 | http://purl.uniprot.org/core/pages | "18991-19001"xsd:string |
| http://purl.uniprot.org/citations/20410302 | http://purl.uniprot.org/core/title | "Mammalian target of rapamycin (mTOR) and S6 kinase down-regulate phospholipase D2 basal expression and function."xsd:string |
| http://purl.uniprot.org/citations/20410302 | http://purl.uniprot.org/core/volume | "285"xsd:string |
| http://purl.uniprot.org/citations/20410302 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/20410302 |
| http://purl.uniprot.org/citations/20410302 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/20410302 |
| http://purl.uniprot.org/uniprot/#_A0A8V8TQ52-mappedCitation-20410302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20410302 |
| http://purl.uniprot.org/uniprot/#_A0A7U3S0Q4-mappedCitation-20410302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20410302 |
| http://purl.uniprot.org/uniprot/#_B4DDM0-mappedCitation-20410302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20410302 |
| http://purl.uniprot.org/uniprot/#_B4DZD5-mappedCitation-20410302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20410302 |
| http://purl.uniprot.org/uniprot/#_B3KX59-mappedCitation-20410302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20410302 |
| http://purl.uniprot.org/uniprot/#_B4E2H2-mappedCitation-20410302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20410302 |
| http://purl.uniprot.org/uniprot/#_B7Z905-mappedCitation-20410302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20410302 |
| http://purl.uniprot.org/uniprot/#_P10145-mappedCitation-20410302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20410302 |
| http://purl.uniprot.org/uniprot/#_P42345-mappedCitation-20410302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20410302 |
| http://purl.uniprot.org/uniprot/#_Q86YQ7-mappedCitation-20410302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20410302 |
| http://purl.uniprot.org/uniprot/#_O14939-mappedCitation-20410302 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/20410302 |