| http://purl.uniprot.org/citations/20410883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20410883 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/20410883 | http://www.w3.org/2000/01/rdf-schema#comment | "DNA methylation is an important epigenetic mark in many eukaryotes. In plants, 24-nucleotide small interfering RNAs (siRNAs) bound to the effector protein, Argonaute 4 (AGO4), can direct de novo DNA methylation by the methyltransferase DRM2 (refs 2, 4-6). Here we report a new regulator of RNA-directed DNA methylation (RdDM) in Arabidopsis: RDM1. Loss-of-function mutations in the RDM1 gene impair the accumulation of 24-nucleotide siRNAs, reduce DNA methylation, and release transcriptional gene silencing at RdDM target loci. RDM1 encodes a small protein that seems to bind single-stranded methyl DNA, and associates and co-localizes with RNA polymerase II (Pol II, also known as NRPB), AGO4 and DRM2 in the nucleus. Our results indicate that RDM1 is a component of the RdDM effector complex and may have a role in linking siRNA production with pre-existing or de novo cytosine methylation. Our results also indicate that, although RDM1 and Pol V (also known as NRPE) may function together at some RdDM target sites in the peri-nucleolar siRNA processing centre, Pol II rather than Pol V is associated with the RdDM effector complex at target sites in the nucleoplasm."xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature09025"xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature09025"xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.uniprot.org/core/author | "Gao Z."xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.uniprot.org/core/author | "Gao Z."xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.uniprot.org/core/author | "Jin H."xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.uniprot.org/core/author | "Jin H."xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.uniprot.org/core/author | "He X."xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.uniprot.org/core/author | "Lin H."xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.uniprot.org/core/author | "Lin H."xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.uniprot.org/core/author | "Lorkovic Z.J."xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.uniprot.org/core/author | "Lorkovic Z.J."xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.uniprot.org/core/author | "Qian W."xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.uniprot.org/core/author | "Qian W."xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.uniprot.org/core/author | "Zhang S."xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.uniprot.org/core/author | "Xie M."xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.uniprot.org/core/author | "Xie M."xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.uniprot.org/core/author | "Lagrange T."xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.uniprot.org/core/author | "Lagrange T."xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.uniprot.org/core/author | "Pontier D."xsd:string |
| http://purl.uniprot.org/citations/20410883 | http://purl.uniprot.org/core/author | "Pontier D."xsd:string |